A novel viral strategy for host factor recruitment: The co-opted proteasomal Rpn11 protein interaction hub in cooperation with subverted actin filaments are targeted to deliver cytosolic host factors for viral replication

Melissa Molho; Wenwu Lin; Peter D. Nagy

doi:10.1371/journal.ppat.1009680

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Peer-reviewed

Research Article

A novel viral strategy for host factor recruitment: The co-opted proteasomal Rpn11 protein interaction hub in cooperation with subverted actin filaments are targeted to deliver cytosolic host factors for viral replication

Melissa Molho,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft

Affiliation Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America

https://orcid.org/0000-0002-9021-4920

⨯
Wenwu Lin,

Roles Investigation, Methodology

Affiliation Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Peter D. Nagy

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: pdnagy2@uky.edu

Affiliation Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America

https://orcid.org/0000-0003-4164-1237

⨯

A novel viral strategy for host factor recruitment: The co-opted proteasomal Rpn11 protein interaction hub in cooperation with subverted actin filaments are targeted to deliver cytosolic host factors for viral replication

Melissa Molho,
Wenwu Lin,
Peter D. Nagy

Published: June 23, 2021
https://doi.org/10.1371/journal.ppat.1009680

About the Authors

Melissa Molho

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft

Affiliation Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America

https://orcid.org/0000-0002-9021-4920

Wenwu Lin

Roles Investigation, Methodology

Affiliation Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America

Peter D. Nagy

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: pdnagy2@uky.edu

Affiliation Department of Plant Pathology, University of Kentucky, Lexington, Kentucky, United States of America

https://orcid.org/0000-0003-4164-1237

Competing Interests

The authors have declared that no competing interests exist.

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Yeast
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Actin filaments
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Fermentation
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Viral replication
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Leaves
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Actins
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Protein interactions
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Legionella
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