About the Authors

Joshua J. Sims

Roles Conceptualization, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

Affiliation Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Jenny A. Greig

Roles Formal analysis, Methodology, Project administration, Writing – original draft, Writing – review & editing

Affiliation Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Kristofer T. Michalson

Roles Methodology, Resources, Writing – original draft, Writing – review & editing

Affiliation Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Sharon Lian

Roles Investigation

Affiliation Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

R. Alexander Martino

Roles Investigation

Affiliation Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Rosemary Meggersee

Roles Investigation

Affiliation Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Kevin B. Turner

Roles Investigation, Methodology

Affiliation Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Kalyani Nambiar

Roles Resources

Affiliation Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Cecilia Dyer

Roles Methodology, Resources

Affiliation Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Christian Hinderer

Roles Conceptualization, Methodology

Affiliation Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Makoto Horiuchi

Roles Investigation

Affiliation Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Hanying Yan

Roles Formal analysis

Affiliation Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Xin Huang

Roles Formal analysis, Software

Affiliation Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Shu-Jen Chen

Roles Investigation

Affiliation Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

James M. Wilson

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

wilsonjm@upenn.edu

Affiliation Gene Therapy Program, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: JMW is a paid advisor to and holds equity in Scout Bio and Passage Bio; he also has sponsored research agreements with Amicus Therapeutics, Biogen, Elaaj Bio, FA212, Janssen, Passage Bio, and Scout Bio, which are licensees of University of Pennsylvania technology. He also has a sponsored research agreement with G2 Bio. JMW holds equity in the G2 Bio-associated asset companies. J.M.W., J.J.S., C.H., J.A.G., M.H., K.N., K.B.T., and S.J.C. are inventors on patents/patents filed by the University of Pennsylvania.