About the Authors

Huihui Mou

Contributed equally to this work with: Huihui Mou, Brian D. Quinlan, Haiyong Peng

Roles Conceptualization, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, United States of America

Brian D. Quinlan

Contributed equally to this work with: Huihui Mou, Brian D. Quinlan, Haiyong Peng

Roles Investigation

Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, United States of America

Haiyong Peng

Contributed equally to this work with: Huihui Mou, Brian D. Quinlan, Haiyong Peng

Roles Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, United States of America

Guanqun Liu

Roles Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, United States of America

Yan Guo

Roles Investigation, Writing – review & editing

Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, United States of America

Shoujiao Peng

Roles Investigation

Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, United States of America

Lizhou Zhang

Roles Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, United States of America

Meredith E. Davis-Gardner

Roles Methodology, Writing – review & editing

Current address: Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, United States of America; Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, United States of America

Matthew R. Gardner

Roles Methodology, Resources, Writing – review & editing

Current address: Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America

Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, United States of America

Gogce Crynen

Roles Software

Affiliation Bioinformatics and Statistics Core, The Scripps Research Institute, Jupiter, FL, United States of America

Lindsey B. DeVaux

Roles Investigation

Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, United States of America

Zhi Xiang Voo

Roles Investigation

Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, United States of America

Charles C. Bailey

Roles Resources

Affiliation Emmune, Inc., Juno Beach, FL, United States of America

Michael D. Alpert

Roles Resources

Affiliation Emmune, Inc., Juno Beach, FL, United States of America

Christoph Rader

Roles Supervision

crader@scripps.edu (CR); gackm@ccf.org (MUG); hchoe@scripps.edu (HC); mfarzan@scripps.edu (MF)

Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, United States of America

Michaela U. Gack

Roles Supervision

crader@scripps.edu (CR); gackm@ccf.org (MUG); hchoe@scripps.edu (HC); mfarzan@scripps.edu (MF)

Affiliation Florida Research and Innovation Center, Cleveland Clinic, Port Saint Lucie, FL, United States of America

Hyeryun Choe

Roles Supervision

crader@scripps.edu (CR); gackm@ccf.org (MUG); hchoe@scripps.edu (HC); mfarzan@scripps.edu (MF)

Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, United States of America

Michael Farzan

Roles Conceptualization, Funding acquisition, Supervision, Visualization, Writing – original draft, Writing – review & editing

crader@scripps.edu (CR); gackm@ccf.org (MUG); hchoe@scripps.edu (HC); mfarzan@scripps.edu (MF)

Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, FL, United States of America

Competing Interests

I have read the journal’s policy and the authors of this manuscript have the following competing interests: M.F., H.M. and B.D.Q had filed a patent for the application of ACE2-Fc variants as a SARS-CoV-2 treatment. M.R.G., C.C.B., M.D.A., and M.F. are all cofounders of, and have an equity interest in Emmune Inc., a biotech company that specializes in the development of antibody-like antiviral therapies.