Natural killer cells expanded in vivo or ex vivo with IL-15 overcomes the inherent susceptibility of CAST mice to lethal infection with orthopoxviruses

Patricia L. Earl; Jeffrey L. Americo; Bernard Moss

doi:10.1371/journal.ppat.1008505

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Peer-reviewed

Research Article

Natural killer cells expanded in vivo or ex vivo with IL-15 overcomes the inherent susceptibility of CAST mice to lethal infection with orthopoxviruses

Patricia L. Earl ,

Contributed equally to this work with: Patricia L. Earl, Jeffrey L. Americo

Roles Investigation, Methodology, Writing – review & editing

Affiliation Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Jeffrey L. Americo ,

Contributed equally to this work with: Patricia L. Earl, Jeffrey L. Americo

Roles Investigation, Methodology, Writing – review & editing

Affiliation Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Bernard Moss

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft

* E-mail: bmoss@NIH.Gov

Affiliation Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

http://orcid.org/0000-0002-2154-8564

⨯

Natural killer cells expanded in vivo or ex vivo with IL-15 overcomes the inherent susceptibility of CAST mice to lethal infection with orthopoxviruses

Patricia L. Earl,
Jeffrey L. Americo,
Bernard Moss

Published: April 22, 2020
https://doi.org/10.1371/journal.ppat.1008505

About the Authors

Patricia L. Earl

Contributed equally to this work with: Patricia L. Earl, Jeffrey L. Americo

Roles Investigation, Methodology, Writing – review & editing

Affiliation Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Jeffrey L. Americo

Contributed equally to this work with: Patricia L. Earl, Jeffrey L. Americo

Roles Investigation, Methodology, Writing – review & editing

Affiliation Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Bernard Moss

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft

* E-mail: bmoss@NIH.Gov

Affiliation Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

http://orcid.org/0000-0002-2154-8564

Competing Interests

The authors have declared that no competing interests exist.

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NK cells
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Luminescence
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T cells
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Mouse models
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Spleen
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Photons
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Cell staining
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Inbred strains
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