PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease

Subhadip Choudhuri; Nisha Jain Garg

doi:10.1371/journal.ppat.1008474

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Open Access

Peer-reviewed

Research Article

PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease

Subhadip Choudhuri,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, Texas, United States of America
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Nisha Jain Garg

Roles Conceptualization, Funding acquisition, Resources, Software, Supervision, Writing – review & editing

* E-mail: nigarg@utmb.edu

Affiliations Department of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, Texas, United States of America, Institute for Human Infections and Immunity (IHII), UTMB, Galveston, Texas, United States of America

http://orcid.org/0000-0002-3453-2369

⨯

PARP1-cGAS-NF-κB pathway of proinflammatory macrophage activation by extracellular vesicles released during Trypanosoma cruzi infection and Chagas disease

Subhadip Choudhuri,
Nisha Jain Garg

Published: April 21, 2020
https://doi.org/10.1371/journal.ppat.1008474

About the Authors

Subhadip Choudhuri

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, Texas, United States of America

Nisha Jain Garg

Roles Conceptualization, Funding acquisition, Resources, Software, Supervision, Writing – review & editing

* E-mail: nigarg@utmb.edu

Affiliations Department of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, Texas, United States of America, Institute for Human Infections and Immunity (IHII), UTMB, Galveston, Texas, United States of America

http://orcid.org/0000-0002-3453-2369

Competing Interests

The authors have declared that no competing interests exist.

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Trypanosoma cruzi
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Chagas disease
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Cytokines
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Parasitic diseases
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Macrophages
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Gene expression
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Inflammatory diseases
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Transcription factors
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