Heparan sulfate attachment receptor is a major selection factor for attenuated enterovirus 71 mutants during cell culture adaptation

Open Access

Peer-reviewed

Research Article

About the Authors

Kyousuke Kobayashi

Roles Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft

Affiliation Neurovirology Project, Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

Katsumi Mizuta

Roles Data curation, Resources

Affiliation Department of Microbiology, Yamagata Prefectural Institute of Public Health, Yamagata, Japan

Satoshi Koike

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliation Neurovirology Project, Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

The authors have declared that no competing interests exist.

Cell cultures
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Microbial mutation
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Substitution mutation
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Computer software
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Mutation detection
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Viral replication
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RNA viruses
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Viral genomics
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