Pathogenicity island excision during an infection by Salmonella enterica serovar Enteritidis is required for crossing the intestinal epithelial barrier in mice to cause systemic infection

Catalina Pardo-Roa; Geraldyne A. Salazar; Loreani P. Noguera; Francisco J. Salazar-Echegarai; Omar P. Vallejos; Isidora D. Suazo; Bárbara M. Schultz; Irenice Coronado-Arrázola; Alexis M. Kalergis; Susan M. Bueno

doi:10.1371/journal.ppat.1008152

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Open Access

Peer-reviewed

Research Article

Pathogenicity island excision during an infection by Salmonella enterica serovar Enteritidis is required for crossing the intestinal epithelial barrier in mice to cause systemic infection

Catalina Pardo-Roa,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliation Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile

http://orcid.org/0000-0002-5409-225X

⨯
Geraldyne A. Salazar,

Roles Data curation, Investigation, Methodology, Writing – original draft

Affiliation Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile
⨯
Loreani P. Noguera,

Roles Investigation, Methodology, Writing – original draft

Affiliation Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile

http://orcid.org/0000-0002-6373-5376

⨯
Francisco J. Salazar-Echegarai,

Roles Methodology

Affiliation Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile

http://orcid.org/0000-0001-6709-699X

⨯
Omar P. Vallejos,

Roles Methodology

Affiliation Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile

http://orcid.org/0000-0002-5203-7062

⨯
Isidora D. Suazo,

Roles Methodology, Writing – original draft

Affiliation Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile

http://orcid.org/0000-0001-8274-7471

⨯
Bárbara M. Schultz,

Roles Writing – original draft

Affiliation Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile

http://orcid.org/0000-0002-6201-6978

⨯
Irenice Coronado-Arrázola,

Roles Data curation

Affiliation Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile

http://orcid.org/0000-0001-5418-2768

⨯
Alexis M. Kalergis,

Roles Funding acquisition, Resources, Writing – original draft, Writing – review & editing

Affiliations Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile, Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile
⨯
Susan M. Bueno

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: sbueno@bio.puc.cl

Affiliation Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile

http://orcid.org/0000-0002-7551-8088

⨯

Pathogenicity island excision during an infection by Salmonella enterica serovar Enteritidis is required for crossing the intestinal epithelial barrier in mice to cause systemic infection

Catalina Pardo-Roa,
Geraldyne A. Salazar,
Loreani P. Noguera,
Francisco J. Salazar-Echegarai,
Omar P. Vallejos,
Isidora D. Suazo,
Bárbara M. Schultz,
Irenice Coronado-Arrázola,
Alexis M. Kalergis,
Susan M. Bueno

Published: December 4, 2019
https://doi.org/10.1371/journal.ppat.1008152

About the Authors

Catalina Pardo-Roa

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliation Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile

http://orcid.org/0000-0002-5409-225X

Geraldyne A. Salazar

Roles Data curation, Investigation, Methodology, Writing – original draft

Loreani P. Noguera

Roles Investigation, Methodology, Writing – original draft

http://orcid.org/0000-0002-6373-5376

Francisco J. Salazar-Echegarai

Roles Methodology

http://orcid.org/0000-0001-6709-699X

Omar P. Vallejos

Roles Methodology

http://orcid.org/0000-0002-5203-7062

Isidora D. Suazo

Roles Methodology, Writing – original draft

http://orcid.org/0000-0001-8274-7471

Bárbara M. Schultz

Roles Writing – original draft

http://orcid.org/0000-0002-6201-6978

Irenice Coronado-Arrázola

Roles Data curation

http://orcid.org/0000-0001-5418-2768

Alexis M. Kalergis

Roles Funding acquisition, Resources, Writing – original draft, Writing – review & editing

Affiliations Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile, Departamento de Endocrinología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile

Susan M. Bueno

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: sbueno@bio.puc.cl

http://orcid.org/0000-0002-7551-8088

Competing Interests

The authors have declared that no competing interests exist.

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Gastrointestinal tract
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Salmonellosis
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Salmonella
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