Reining in the CD8+ T cell: Respiratory virus infection and PD-1-mediated T-cell impairment

Meredith C. Rogers; John V. Williams

doi:10.1371/journal.ppat.1007387

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Reining in the CD8+ T cell: Respiratory virus infection and PD-1-mediated T-cell impairment

Meredith C. Rogers ,

* E-mail: meredith.rogers@vanderbilt.edu (MCR); jvw@chp.edu (JVW)

Affiliations Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

http://orcid.org/0000-0003-1798-6294

⨯
John V. Williams

* E-mail: meredith.rogers@vanderbilt.edu (MCR); jvw@chp.edu (JVW)

Affiliations Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

http://orcid.org/0000-0001-8377-5175

⨯

Reining in the CD8+ T cell: Respiratory virus infection and PD-1-mediated T-cell impairment

Meredith C. Rogers,
John V. Williams

Published: January 3, 2019
https://doi.org/10.1371/journal.ppat.1007387

About the Authors

Meredith C. Rogers

* E-mail: meredith.rogers@vanderbilt.edu (MCR); jvw@chp.edu (JVW)

Affiliations Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

http://orcid.org/0000-0003-1798-6294

John V. Williams

* E-mail: meredith.rogers@vanderbilt.edu (MCR); jvw@chp.edu (JVW)

Affiliations Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

http://orcid.org/0000-0001-8377-5175

Competing Interests

JVW serves on the Scientific Advisory Board of Quidel and an Independent Data Monitoring Committee for GlaxoSmithKline, neither of which has any relation to this review. MCR declares no conflict of interest.

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T cells
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Respiratory infections
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T cell receptors
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Cytotoxic T cells
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Respiratory physiology
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Viral vaccines
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Lung and intrathoracic tumors
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