Herpes simplex viruses activate phospholipid scramblase to redistribute phosphatidylserines and Akt to the outer leaflet of the plasma membrane and promote viral entry

Natalia Cheshenko; Carl Pierce; Betsy C. Herold

doi:10.1371/journal.ppat.1006766

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Peer-reviewed

Research Article

Herpes simplex viruses activate phospholipid scramblase to redistribute phosphatidylserines and Akt to the outer leaflet of the plasma membrane and promote viral entry

Natalia Cheshenko,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Carl Pierce,

Roles Conceptualization, Formal analysis, Investigation, Methodology

Affiliation Department of Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯
Betsy C. Herold

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft

* E-mail: betsy.herold@einstein.yu.edu

Affiliations Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America
⨯

Herpes simplex viruses activate phospholipid scramblase to redistribute phosphatidylserines and Akt to the outer leaflet of the plasma membrane and promote viral entry

Natalia Cheshenko,
Carl Pierce,
Betsy C. Herold

Published: January 2, 2018
https://doi.org/10.1371/journal.ppat.1006766

About the Authors

Natalia Cheshenko

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, United States of America

Carl Pierce

Roles Conceptualization, Formal analysis, Investigation, Methodology

Affiliation Department of Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America

Betsy C. Herold

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft

* E-mail: betsy.herold@einstein.yu.edu

Affiliations Department of Pediatrics, Albert Einstein College of Medicine, Bronx, New York, United States of America, Department of Microbiology-Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America

Competing Interests

The authors have declared that no competing interests exist

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Cell membranes
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Small interfering RNA
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Cell staining
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Transfection
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Scramblase
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Nuclear staining
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Viral entry
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DAPI staining
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