About the Authors

Thomas J. Scriba

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

thomas.scriba@uct.ac.za

‡ TJS, APN, and SS share first authorship on this work.

Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

Adam Penn-Nicholson

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

‡ TJS, APN, and SS share first authorship on this work.

Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

Smitha Shankar

Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

‡ TJS, APN, and SS share first authorship on this work.

Affiliation The Center for Infectious Disease Research, Seattle, WA, United States of America

Tom Hraha

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Somalogic Inc, Boulder, CO, United States of America

Ethan G. Thompson

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation The Center for Infectious Disease Research, Seattle, WA, United States of America

David Sterling

Roles Formal analysis, Investigation, Methodology, Writing – review & editing

Affiliation Somalogic Inc, Boulder, CO, United States of America

Elisa Nemes

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

Fatoumatta Darboe

Roles Methodology, Writing – review & editing

Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

Sara Suliman

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

Lynn M. Amon

Roles Formal analysis, Methodology, Writing – review & editing

Affiliation The Center for Infectious Disease Research, Seattle, WA, United States of America

Hassan Mahomed

Roles Investigation, Writing – review & editing

Affiliations South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa, Now at Metro District Health Services, Western Cape Government: Health and Division of Public Health and Health Systems, Department of Global Health, Faculty of Health Sciences and Medicine, Stellenbosch University, Cape Town, South Africa

Mzwandile Erasmus

Roles Methodology, Writing – review & editing

Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

Wendy Whatney

Roles Methodology, Writing – review & editing

Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

John L. Johnson

Roles Investigation, Writing – review & editing

Affiliation Tuberculosis Research Unit, Department of Medicine, Case Western Reserve University and University Hospitals Case Cleveland Medical Center, Cleveland, OH, United States of America

W. Henry Boom

Roles Investigation, Writing – review & editing

Affiliation Tuberculosis Research Unit, Department of Medicine, Case Western Reserve University and University Hospitals Case Cleveland Medical Center, Cleveland, OH, United States of America

Mark Hatherill

Roles Investigation, Methodology, Writing – review & editing

Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

Joe Valvo

Roles Methodology, Writing – review & editing

Affiliation The Center for Infectious Disease Research, Seattle, WA, United States of America

Mary Ann De Groote

Roles Investigation, Methodology, Writing – review & editing

Affiliation Somalogic Inc, Boulder, CO, United States of America

Urs A. Ochsner

Roles Investigation, Methodology, Writing – review & editing

Affiliation Somalogic Inc, Boulder, CO, United States of America

Alan Aderem

Contributed equally to this work with: Alan Aderem, Willem A. Hanekom, Daniel E. Zak

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

Affiliation The Center for Infectious Disease Research, Seattle, WA, United States of America

Willem A. Hanekom

Contributed equally to this work with: Alan Aderem, Willem A. Hanekom, Daniel E. Zak

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation South African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine & Division of Immunology, Department of Pathology, University of Cape Town, Cape Town, South Africa

Daniel E. Zak

Contributed equally to this work with: Alan Aderem, Willem A. Hanekom, Daniel E. Zak

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation The Center for Infectious Disease Research, Seattle, WA, United States of America

other members of the ACS cohort study team

Membership of the ACS cohort study team is provided in the Acknowledgments.

Competing Interests

TJS, APN, EGT, AA, WAH, and DEZ are co-inventors on a patent of the 16-gene transcriptomic correlate of risk of TB. DS, MAdG, TH and UAO are current or former employees of or hold stock options in SomaLogic, Inc. and received funding from the Bill & Melinda Gates Foundation (OPP1091720). This does not alter our adherence to all PLOS Pathogens policies on sharing data and materials. All other authors have declared that no competing interests exist.