A novel genetic technique in Plasmodium berghei allows liver stage analysis of genes required for mosquito stage development and demonstrates that de novo heme synthesis is essential for liver stage development in the malaria parasite

Upeksha L. Rathnapala; Christopher D. Goodman; Geoffrey I. McFadden

doi:10.1371/journal.ppat.1006396

Loading metrics

Open Access

Peer-reviewed

Research Article

A novel genetic technique in Plasmodium berghei allows liver stage analysis of genes required for mosquito stage development and demonstrates that de novo heme synthesis is essential for liver stage development in the malaria parasite

Upeksha L. Rathnapala,

Affiliation School of BioSciences, University of Melbourne, Parkville, Victoria, Australia

http://orcid.org/0000-0001-6259-616X

⨯
Christopher D. Goodman ,

* E-mail: deang@unimelb.edu.au

¶‡ These authors are joint senior authors on this work.

Affiliation School of BioSciences, University of Melbourne, Parkville, Victoria, Australia

http://orcid.org/0000-0002-8923-7594

⨯
Geoffrey I. McFadden

¶‡ These authors are joint senior authors on this work.

Affiliation School of BioSciences, University of Melbourne, Parkville, Victoria, Australia
⨯

A novel genetic technique in Plasmodium berghei allows liver stage analysis of genes required for mosquito stage development and demonstrates that de novo heme synthesis is essential for liver stage development in the malaria parasite

Upeksha L. Rathnapala,
Christopher D. Goodman,
Geoffrey I. McFadden

Published: June 15, 2017
https://doi.org/10.1371/journal.ppat.1006396

About the Authors

Upeksha L. Rathnapala

Affiliation School of BioSciences, University of Melbourne, Parkville, Victoria, Australia

http://orcid.org/0000-0001-6259-616X

Christopher D. Goodman

* E-mail: deang@unimelb.edu.au

¶‡ These authors are joint senior authors on this work.

Affiliation School of BioSciences, University of Melbourne, Parkville, Victoria, Australia

http://orcid.org/0000-0002-8923-7594

Geoffrey I. McFadden

¶‡ These authors are joint senior authors on this work.

Affiliation School of BioSciences, University of Melbourne, Parkville, Victoria, Australia

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceptualization: CDG GIM. Data curation: ULR CDG. Formal analysis: CDG ULR. Funding acquisition: GIM. Investigation: ULR CDG. Methodology: ULR CDG. Project administration: CDG GIM. Resources: ULR CDG GIM. Supervision: CDG GIM. Validation: ULR CDG GIM. Visualization: ULR CDG GIM. Writing – original draft: ULR. Writing – review & editing: ULR CDG GIM.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Parasitic diseases
Is the Subject Area "Parasitic diseases" applicable to this article?

Thanks for your feedback.
Sporozoites
Is the Subject Area "Sporozoites" applicable to this article?

Thanks for your feedback.
Parasitic life cycles
Is the Subject Area "Parasitic life cycles" applicable to this article?

Thanks for your feedback.
Oocysts
Is the Subject Area "Oocysts" applicable to this article?

Thanks for your feedback.
Malarial parasites
Is the Subject Area "Malarial parasites" applicable to this article?

Thanks for your feedback.
Heme
Is the Subject Area "Heme" applicable to this article?

Thanks for your feedback.
Mosquitoes
Is the Subject Area "Mosquitoes" applicable to this article?

Thanks for your feedback.
Plasmodium
Is the Subject Area "Plasmodium" applicable to this article?

Thanks for your feedback.