About the Authors

Zeyu Lin

Affiliation Departments of Virology, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America

Joseph Cantone

Affiliation Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America

Hao Lu

Affiliation Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America

Beata Nowicka-Sans

† Deceased.

Affiliation Departments of Virology, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America

Tricia Protack

Affiliation Departments of Virology, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America

Tian Yuan

Affiliation Discovery Chemistry Platforms, Princeton, New Jersey, United States of America

Hong Yang

Affiliation Discovery Chemistry Platforms, Princeton, New Jersey, United States of America

Zheng Liu

Affiliation Discovery Chemistry, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America

Dieter Drexler

Affiliation Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America

Alicia Regueiro-Ren

Affiliation Discovery Chemistry, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America

Nicholas A. Meanwell

Affiliation Discovery Chemistry, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America

Mark Cockett

Affiliation Departments of Virology, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America

Mark Krystal

Affiliation Departments of Virology, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America

Max Lataillade

Affiliation Global Clinical Development, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America

Ira B. Dicker

Ira.B.Dicker@ViiVHealthcare.com, Iradicker@yahoo.com

Affiliation Departments of Virology, Bristol-Myers Squibb Research & Development, Wallingford, Connecticut, United States of America

Competing Interests

We report the following conflicts of interest: ZLin, JC, HL, BNS, TP, TY, HY, ZLiu, DD, ARR, NAM, MC, MK, ML and ID are employees or former employees of and shareholders in Bristol-Myers Squibb. This does not alter our adherence to all PLOS policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ZLin JC DD ML ID. Performed the experiments: ZLin JC BNS TP TY HY ZLiu. Analyzed the data: ZLin JC HL BNS TP TY DD MK ID. Contributed reagents/materials/analysis tools: ZLin JC HL BNS TP TY HY ZLiu ARR ID. Wrote the paper: ZLin JC HL DD NAM MC MK ID.