Evolutionary Paradigms from Ancient and Ongoing Conflicts between the Lentiviral Vif Protein and Mammalian APOBEC3 Enzymes

Reuben S. Harris; Brett D. Anderson

doi:10.1371/journal.ppat.1005958

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Evolutionary Paradigms from Ancient and Ongoing Conflicts between the Lentiviral Vif Protein and Mammalian APOBEC3 Enzymes

Reuben S. Harris ,

* E-mail: rsh@umn.edu

Affiliations Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota, United States of America, Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Center for Genome Engineering, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, United States of America
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Brett D. Anderson

Affiliation Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Center for Genome Engineering, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, United States of America
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Evolutionary Paradigms from Ancient and Ongoing Conflicts between the Lentiviral Vif Protein and Mammalian APOBEC3 Enzymes

Reuben S. Harris,
Brett D. Anderson

Published: December 1, 2016
https://doi.org/10.1371/journal.ppat.1005958

About the Authors

Reuben S. Harris

* E-mail: rsh@umn.edu

Affiliations Howard Hughes Medical Institute, University of Minnesota, Minneapolis, Minnesota, United States of America, Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Center for Genome Engineering, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, United States of America

Brett D. Anderson

Affiliation Department of Biochemistry, Molecular Biology and Biophysics, Masonic Cancer Center, Center for Genome Engineering, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, United States of America

Competing Interests

I have read the journal's policy and have the following conflicts: RSH is a cofounder of ApoGen Biotechnologies Inc. BDA does not have competing interests.

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Primates
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HIV-1
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Drug interactions
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Lentivirus
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Mammalian genomics
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Evolutionary immunology
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