About the Authors

Ester Vázquez-Fernández

Affiliations Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada, Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

Matthijn R. Vos

Affiliation FEI Company, Nanoport Europe, Eindhoven, The Netherlands

Pavel Afanasyev

Affiliations Institute of Biology Leiden, NeCEN, Leiden, The Netherlands, The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, The Netherlands

Lino Cebey

Affiliations Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada, Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

Alejandro M. Sevillano

Affiliation CIMUS Biomedical Research Institute University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain

Enric Vidal

Affiliation IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, Bellaterra, Catalonia, Spain

Isaac Rosa

Affiliation CIMUS Biomedical Research Institute University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain

Ludovic Renault

Current address: Institute of Biology Leiden, NeCEN, Leiden, The Netherlands.

Affiliation Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

Adriana Ramos

Current address: Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Affiliation CIMUS Biomedical Research Institute University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain

Peter J. Peters

Affiliation The Maastricht Multimodal Molecular Imaging Institute, Maastricht University, Maastricht, The Netherlands

José Jesús Fernández

Affiliation Centro Nacional de Biotecnologia - CSIC, Campus Universidad Autónoma, Madrid, Spain

Marin van Heel

Affiliations Institute of Biology Leiden, NeCEN, Leiden, The Netherlands, Brazilian Nanotechnology National Laboratory - LNNano, CNPEM, Campinas, São Paulo, Brazil, Faculty of Natural Science, Imperial College London, London, United Kingdom

Howard S. Young

hyoung@ualberta.ca (HSY); jesus.requena@usc.es (JRR); wille@ualberta.ca (HW)

Affiliation Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada

Jesús R. Requena

hyoung@ualberta.ca (HSY); jesus.requena@usc.es (JRR); wille@ualberta.ca (HW)

Affiliation CIMUS Biomedical Research Institute University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain

Holger Wille

hyoung@ualberta.ca (HSY); jesus.requena@usc.es (JRR); wille@ualberta.ca (HW)

Affiliations Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada, Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada

Competing Interests

MRV is an employee of FEI Company (Eindhoven, The Netherlands), this does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceptualization: MRV HSY JRR HW. Data curation: EVF LC LR. Formal analysis: EVF HSY JRR HW. Funding acquisition: JJF JRR HW. Investigation: EVF MRV AMS EV IR AR JRR HW. Methodology: MvH HSY. Project administration: JRR HW. Resources: PJP MvH JRR. Software: PA JJF MvH HSY. Supervision: HSY JRR HW. Visualization: EVF PA JJF. Writing – original draft: EVF JRR HW.