Antibodies with ‘Original Antigenic Sin’ Properties Are Valuable Components of Secondary Immune Responses to Influenza Viruses

Susanne L. Linderman; Scott E. Hensley

doi:10.1371/journal.ppat.1005806

Loading metrics

Open Access

Peer-reviewed

Research Article

Antibodies with ‘Original Antigenic Sin’ Properties Are Valuable Components of Secondary Immune Responses to Influenza Viruses

Susanne L. Linderman,

Affiliations Department of Microbiology, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Wistar Institute, Philadelphia, Pennsylvania, United States of America

http://orcid.org/0000-0003-3297-3774

⨯
Scott E. Hensley

* E-mail: hensley@mail.med.upenn.edu

Affiliations Department of Microbiology, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Wistar Institute, Philadelphia, Pennsylvania, United States of America
⨯

Antibodies with ‘Original Antigenic Sin’ Properties Are Valuable Components of Secondary Immune Responses to Influenza Viruses

Susanne L. Linderman,
Scott E. Hensley

Published: August 18, 2016
https://doi.org/10.1371/journal.ppat.1005806

About the Authors

Susanne L. Linderman

Affiliations Department of Microbiology, Perelman School of Medicine, The University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Wistar Institute, Philadelphia, Pennsylvania, United States of America

http://orcid.org/0000-0003-3297-3774

Scott E. Hensley

* E-mail: hensley@mail.med.upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SLL SEH. Performed the experiments: SLL. Analyzed the data: SLL SEH. Wrote the paper: SLL SEH.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Microbial mutation
Is the Subject Area "Microbial mutation" applicable to this article?

Thanks for your feedback.
Influenza
Is the Subject Area "Influenza" applicable to this article?

Thanks for your feedback.
Hybridomas
Is the Subject Area "Hybridomas" applicable to this article?

Thanks for your feedback.
Influenza viruses
Is the Subject Area "Influenza viruses" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Antibodies
Is the Subject Area "Antibodies" applicable to this article?

Thanks for your feedback.
H1N1
Is the Subject Area "H1N1" applicable to this article?

Thanks for your feedback.
B cells
Is the Subject Area "B cells" applicable to this article?

Thanks for your feedback.