About the Authors

Wesley C. Van Voorhis

wesley@uw.edu.

Affiliation Departments of Medicine, Microbiology, and Global Health, Center for Emerging and Re-emerging Infectious Diseases (CERID) University of Washington, Seattle, Washington, United States of America

John H. Adams

Affiliation Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America

Roberto Adelfio

Affiliations Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

Vida Ahyong

Affiliation Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California, San Francisco, California, United States of America

Myles H. Akabas

Affiliation Departments of Physiology & Biophysics, Neuroscience and Medicine, Albert Einstein College of Medicine, New York, New York, United States of America

Pietro Alano

Affiliation Dipartimento Malattie Infettive, Parassitarie ed Immunomediate Istituto Superiore di Sanità, Roma, Italia

Aintzane Alday

Affiliation BBD BioPhenix SL–BIOBIDE, Donostia, Gipuzkoa, Spain

Yesmalie Alemán Resto

Affiliation Bigelow Laboratory for Ocean Sciences, East Boothbay, Maine, United States of America

Aishah Alsibaee

Affiliation Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland

Ainhoa Alzualde

Affiliation BBD BioPhenix SL–BIOBIDE, Donostia, Gipuzkoa, Spain

Katherine T. Andrews

Affiliations Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia, QIMR Berghofer Medical Research Institute Herston, Brisbane, Australia

Simon V. Avery

Affiliation School of Life Sciences, University of Nottingham, Nottingham, Nottinghamshire, England, United Kingdom

Vicky M. Avery

Affiliation Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia

Lawrence Ayong

Affiliation Institut Pasteur Korea, Pangyo Techno-Valley, Gyeonggi Province, Korea

Mark Baker

Affiliation Clinical Pharmacology, Novartis Consumer Health, Nyon, Switzerland

Stephen Baker

Affiliations Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, Nuffield Department of Clinical Medicine, Centre for Tropical Medicine, Oxford University, Oxford, England, United Kingdom, The London School of Hygiene and Tropical Medicine, London, England, United Kingdom

Choukri Ben Mamoun

Affiliation Internal Medicine, Yale University, New Haven, Connecticut, United States of America

Sangeeta Bhatia

Affiliation Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Quentin Bickle

Affiliation Department of Immunology & Infection, London School of Hygiene and Tropical Medicine, London, England, United Kingdom

Lotfi Bounaadja

Affiliation Museum of National History, Sorbonne Universities, Paris, France

Tana Bowling

Affiliation SCYNEXIS, Inc., Durham, North Carolina, United States of America

Jürgen Bosch

Affiliation Department of Biochemistry and Molecular Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, Untied States of America

Lauren E. Boucher

Affiliation Department of Biochemistry and Molecular Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, Untied States of America

Fabrice F. Boyom

Affiliation Department of Biochemistry, University of Yaoundé, Yaoundé, Cameroon

Jose Brea

Affiliation CIMUS Research Centre, University of Santiago de Compostela, Santiago de Compostela, A Coruña, Spain

Marian Brennan

Affiliation Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland

Audrey Burton

Affiliation SCYNEXIS, Inc., Durham, North Carolina, United States of America

Conor R. Caffrey

Affiliation Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

Grazia Camarda

Affiliation Dipartimento Malattie Infettive, Parassitarie ed Immunomediate Istituto Superiore di Sanità, Roma, Italia

Manuela Carrasquilla

Current address: Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom

Affiliation Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania, United States of America

Dee Carter

Affiliation School of Life and Environmental Sciences, University of Sydney, Darlington New South Wales, Australia

Maria Belen Cassera

Affiliation Department of Biochemistry and Virginia Tech Center for Drug Discovery, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America

Ken Chih-Chien Cheng

Affiliation National Center of Advancing Translational Sciences, NIH, Bethesda, Maryland, United States of America

Worathad Chindaudomsate

Affiliation Department of Biochemistry, Mahidol University, Bangkok, Thailand

Anthony Chubb

Affiliation Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland

Beatrice L. Colon

Affiliation Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America

Daisy D. Colón-López

Affiliation Department of Biochemistry and Molecular Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, Untied States of America

Yolanda Corbett

Affiliation Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy

Gregory J. Crowther

Affiliation Departments of Medicine, Microbiology, and Global Health, Center for Emerging and Re-emerging Infectious Diseases (CERID) University of Washington, Seattle, Washington, United States of America

Noemi Cowan

Affiliations Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

Sarah D’Alessandro

Affiliation Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy

Na Le Dang

Affiliation Department of Pathology and Immunology, Washington University in St Louis, St. Louis, Missouri, United States of America

Michael Delves

Affiliation Department of Life Sciences, Imperial College London, London, England, United Kingdom

Joseph L. DeRisi

Affiliation Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California, San Francisco, California, United States of America

Alan Y. Du

Affiliation Division of Pharmacology and Drug Discovery, Department of Pediatrics, School of Medicine University of California San Diego, La Jolla, California, United States of America

Sandra Duffy

Affiliation Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia

Shimaa Abd El-Salam El-Sayed

Affiliations National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan, Department of Biochemistry and Chemistry of nutrition, Mansoura University, Mansoura City, Egypt

Michael T. Ferdig

Affiliation Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame Indiana, United States of America

José A. Fernández Robledo

Affiliation Bigelow Laboratory for Ocean Sciences, East Boothbay, Maine, United States of America

David A. Fidock

Affiliation Department of Microbiology & Immunology and Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, United States of America

Isabelle Florent

Affiliation Museum of National History, Sorbonne Universities, Paris, France

Patrick V. T. Fokou

Affiliation Department of Biochemistry, University of Yaoundé, Yaoundé, Cameroon

Ani Galstian

Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

Francisco Javier Gamo

Affiliation Biochemistry and Parasitology Department, Malaria DPU, Diseases of the Developing World (DDW), GlaxoSmithKline R&D, Tres Cantos, Madrid, Spain

Suzanne Gokool

Affiliation Tropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Harrow, Middlesex, England, United Kingdom

Ben Gold

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America

Todd Golub

Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

Gregory M. Goldgof

Affiliation Medical Scientist Training Program, University of California, San Diego, San Diego, California, United States of America

Rajarshi Guha

Affiliation National Center of Advancing Translational Sciences, NIH, Bethesda, Maryland, United States of America

W. Armand Guiguemde

Affiliation Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Nil Gural

Affiliation Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

R. Kiplin Guy

Affiliation Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America

Michael A. E. Hansen

Affiliation Institut Pasteur Korea, Pangyo Techno-Valley, Gyeonggi Province, Korea

Kirsten K. Hanson

Affiliations Dept. of Biology and South Texas Center for Emerging Infectious Diseases, University of Texas, San Antonio, San Antonio, Texas, United States of America, Instituto de Medicina Molecular, Lisboa, Portugal

Andrew Hemphill

Affiliation Institute of Parasitology, University of Berne, Bern, Switzerland

Rob Hooft van Huijsduijnen

Affiliation Medicines for Malaria Venture, Geneva, Switzerland

Takaaki Horii

Affiliation Global Health Research Section, hhc Data Creation Center, Eisai Co., Ltd, Tsukuba-shi, Ibaraki, Japan

Paul Horrocks

Affiliation Institute for Science and Technology in Medicine, Keele University, Keele, Staffordshire, United Kingdom

Tyler B. Hughes

Affiliation Department of Pathology and Immunology, Washington University in St Louis, St. Louis, Missouri, United States of America

Christopher Huston

Affiliation Department of Medicine, College of Medicine, University of Vermont, Burlington, Vermont, United States of America

Ikuo Igarashi

Affiliation National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan

Katrin Ingram-Sieber

Affiliations Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

Maurice A. Itoe

Affiliation Instituto de Medicina Molecular, Lisboa, Portugal

Ajit Jadhav

Affiliation National Center of Advancing Translational Sciences, NIH, Bethesda, Maryland, United States of America

Amornrat Naranuntarat Jensen

Affiliation Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok Thailand

Laran T. Jensen

Affiliation Department of Biochemistry, Mahidol University, Bangkok, Thailand

Rays H. Y. Jiang

Affiliation Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America

Annette Kaiser

Affiliation Medical Research Centre, Institute for Pharmacogenetics, Essen, Germany

Jennifer Keiser

Affiliations Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

Thomas Ketas

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America

Sebastien Kicka

Affiliation Department of Biochemistry, University of Geneva, Geneva, Switzerland

Sunyoung Kim

Affiliation Department of Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America

Kiaran Kirk

Affiliation Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia

Vidya P. Kumar

Affiliation Internal Medicine, Yale University, New Haven, Connecticut, United States of America

Dennis E. Kyle

Affiliation Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America

Maria Jose Lafuente

Affiliation Biochemistry and Parasitology Department, Malaria DPU, Diseases of the Developing World (DDW), GlaxoSmithKline R&D, Tres Cantos, Madrid, Spain

Scott Landfear

Affiliation Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, United States of America

Nathan Lee

Affiliation Medicines for Malaria Venture, Geneva, Switzerland

Sukjun Lee

Affiliation Institut Pasteur Korea, Pangyo Techno-Valley, Gyeonggi Province, Korea

Adele M. Lehane

Affiliation Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia

Fengwu Li

Affiliation Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, United States of America

David Little

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America

Liqiong Liu

Affiliation Department of Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America

Manuel Llinás

Affiliation Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania, United States of America

Maria I. Loza

Affiliation CIMUS Research Centre, University of Santiago de Compostela, Santiago de Compostela, A Coruña, Spain

Aristea Lubar

Affiliation Department of Medicine, University of California San Diego, San Diego, California, United States of America

Leonardo Lucantoni

Affiliation Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia

Isabelle Lucet

Affiliation Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia

Louis Maes

Affiliation University of Antwerp, Department of Biomedical Sciences, Antwerp, Belgium

Dalu Mancama

Affiliation Biosciences Unit, Council for Scientific and Industrial Research, Pretoria, South Africa

Nuha R. Mansour

Affiliation Department of Immunology & Infection, London School of Hygiene and Tropical Medicine, London, England, United Kingdom

Sandra March

Affiliation Health Sciences and Technology/Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Sheena McGowan

Affiliation Department of Microbiology, Monash University, Clayton, Australia

Iset Medina Vera

Affiliation Instituto de Medicina Molecular, Lisboa, Portugal

Stephan Meister

Affiliation Division of Pharmacology and Drug Discovery, Department of Pediatrics, School of Medicine University of California San Diego, La Jolla, California, United States of America

Luke Mercer

Affiliation SCYNEXIS, Inc., Durham, North Carolina, United States of America

Jordi Mestres

Affiliation Chemotargets S.L. and Research Group on Systems Pharmacology, Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Institute of Medical Research and University Pompeu Fabra, Barcelona, Catalonia, Spain

Alvine N. Mfopa

Affiliation Department of Biochemistry, University of Yaoundé, Yaoundé, Cameroon

Raj N. Misra

Affiliation Division of Cancer Therapeutics and Diagnosis, Drug Synthesis and Chemistry Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Seunghyun Moon

Affiliation Institut Pasteur Korea, Pangyo Techno-Valley, Gyeonggi Province, Korea

John P. Moore

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America

Francielly Morais Rodrigues da Costa

Affiliation Graduate Program in Bioinformatics, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

Joachim Müller

Affiliation Institute of Parasitology, University of Berne, Bern, Switzerland

Arantza Muriana

Affiliation BBD BioPhenix SL–BIOBIDE, Donostia, Gipuzkoa, Spain

Stephen Nakazawa Hewitt

Affiliation Departments of Medicine, Microbiology, and Global Health, Center for Emerging and Re-emerging Infectious Diseases (CERID) University of Washington, Seattle, Washington, United States of America

Bakela Nare

Affiliation SCYNEXIS, Inc., Durham, North Carolina, United States of America

Carl Nathan

Affiliation Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, United States of America

Nathalie Narraidoo

Affiliation School of Life Sciences, University of Nottingham, Nottingham, Nottinghamshire, England, United Kingdom

Sujeevi Nawaratna

Affiliations Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia, QIMR Berghofer Medical Research Institute Herston, Brisbane, Australia

Kayode K. Ojo

Affiliation Departments of Medicine, Microbiology, and Global Health, Center for Emerging and Re-emerging Infectious Diseases (CERID) University of Washington, Seattle, Washington, United States of America

Diana Ortiz

Affiliation Department of Molecular Microbiology & Immunology, Oregon Health & Science University, Portland, Oregon, United States of America

Gordana Panic

Affiliations Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

George Papadatos

Affiliation ChEMBL group, European Molecular Biology Laboratory—European Bioinformatics Institute (EMBL-EBI), Hinxton, Cambridgeshire, United Kingdom

Silvia Parapini

Affiliation Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milano, Italy

Kailash Patra

Affiliation Department of Medicine, University of California San Diego, San Diego, California, United States of America

Ngoc Pham

Affiliation Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia

Sarah Prats

Affiliation Biochemistry and Parasitology Department, Malaria DPU, Diseases of the Developing World (DDW), GlaxoSmithKline R&D, Tres Cantos, Madrid, Spain

David M. Plouffe

Affiliation Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

Sally-Ann Poulsen

Affiliation Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia

Anupam Pradhan

Affiliation Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America

Celia Quevedo

Affiliation BBD BioPhenix SL–BIOBIDE, Donostia, Gipuzkoa, Spain

Ronald J. Quinn

Affiliation Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia

Christopher A. Rice

Affiliation Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America

Mohamed Abdo Rizk

Affiliations National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan, Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura City, Egypt

Andrea Ruecker

Affiliation Department of Life Sciences, Imperial College London, London, England, United Kingdom

Robert St. Onge

Affiliation Department of Biochemistry and Stanford Genome Technology Center, Stanford University, Palo Alto, Calilfornia, United States of America

Rafaela Salgado Ferreira

Affiliation Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

Jasmeet Samra

Affiliation Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania, United States of America

Natalie G. Robinett

Affiliations Department of Biochemistry and Molecular Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, Untied States of America, Laboratoire de Chimie Moléculaire, CNRS,—UMR 7509, COB-IRJBD, Mulhouse Cedex, France

Ulrich Schlecht

Affiliation Department of Biochemistry and Stanford Genome Technology Center, Stanford University, Palo Alto, Calilfornia, United States of America

Marjorie Schmitt

Affiliation Laboratoire de Chimie Moléculaire, CNRS,—UMR 7509, COB-IRJBD, Mulhouse Cedex, France

Filipe Silva Villela

Affiliation Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

Francesco Silvestrini

Affiliation Dipartimento Malattie Infettive, Parassitarie ed Immunomediate Istituto Superiore di Sanità, Roma, Italia

Robert Sinden

Affiliation The Jenner Institute, University of Oxford, Oxford, England, United Kingdom

Dennis A. Smith

Affiliation Department of Chemistry, University of Capetown, Capetown, South Africa

Thierry Soldati

Affiliation Department of Biochemistry, University of Geneva, Geneva, Switzerland

Andreas Spitzmüller

Affiliation Chemotargets S.L. and Research Group on Systems Pharmacology, Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Institute of Medical Research and University Pompeu Fabra, Barcelona, Catalonia, Spain

Serge Maximilian Stamm

Affiliation Department of Biochemistry and Molecular Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, Untied States of America

David J. Sullivan

Affiliation H. Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, Maryland, United States of America

William Sullivan

Affiliation Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California, United States of America

Sundari Suresh

Affiliation Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil

Brian M. Suzuki

Affiliation Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California San Francisco, San Francisco, California, United States of America

Yo Suzuki

Affiliation Department of Synthetic Biology and Bioenergy, J. Craig Venter Institute, La Jolla, California, United States of America

S. Joshua Swamidass

Affiliation Department of Life Sciences, Imperial College London, London, England, United Kingdom

Donatella Taramelli

Affiliation Department of Pathology and Immunology, Washington University in St Louis, St. Louis, Missouri, United States of America

Lauve R. Y. Tchokouaha

Affiliation Department of Biochemistry, University of Yaoundé, Yaoundé, Cameroon

Anjo Theron

Affiliation Biosciences Unit, Council for Scientific and Industrial Research, Pretoria, South Africa

David Thomas

Affiliation Broad Institute, Cambridge, Massachusetts, United States of America

Kathryn F. Tonissen

Affiliations Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia, School of Natural Sciences, Griffith University, Nathan, Queensland, Australia

Simon Townson

Affiliation Tropical Parasitic Diseases Unit, Northwick Park Institute for Medical Research, Harrow, Middlesex, England, United Kingdom

Abhai K. Tripathi

Affiliation H. Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, Maryland, United States of America

Valentin Trofimov

Affiliation Department of Biochemistry, University of Geneva, Geneva, Switzerland

Kenneth O. Udenze

Affiliation Center for Global Health and Infectious Diseases Research, Department of Global Health, University of South Florida, Tampa, Florida, United States of America

Imran Ullah

Affiliation Institute for Science and Technology in Medicine, Keele University, Keele, Staffordshire, United Kingdom

Cindy Vallieres

Affiliation School of Life Sciences, University of Nottingham, Nottingham, Nottinghamshire, England, United Kingdom

Edgar Vigil

Affiliation Division of Pharmacology and Drug Discovery, Department of Pediatrics, School of Medicine University of California San Diego, La Jolla, California, United States of America

Joseph M. Vinetz

Affiliation Department of Medicine, University of California San Diego, San Diego, California, United States of America

Phat Voong Vinh

Affiliation Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam

Hoan Vu

Affiliation Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD, Australia

Nao-aki Watanabe

Affiliation Global Health Research Section, hhc Data Creation Center, Eisai Co., Ltd, Tsukuba-shi, Ibaraki, Japan

Kate Weatherby

Affiliation School of Life and Environmental Sciences, University of Sydney, Darlington New South Wales, Australia

Pamela M. White

Affiliation Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California, United States of America

Andrew F. Wilks

Affiliations Hudson Institute of Medical Research; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, SYNthesis Research, Parkville, Victoria, Australia

Elizabeth A. Winzeler

Affiliation Division of Pharmacology and Drug Discovery, Department of Pediatrics, School of Medicine University of California San Diego, La Jolla, California, United States of America

Edward Wojcik

Affiliation Department of Biochemistry and Molecular Biology, LSU Health Sciences Center, New Orleans, Louisiana, United States of America

Melanie Wree

Affiliation Division of Pharmacology and Drug Discovery, Department of Pediatrics, School of Medicine University of California San Diego, La Jolla, California, United States of America

Wesley Wu

Affiliation Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of California, San Francisco, California, United States of America

Naoaki Yokoyama

Affiliation National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan

Paul H. A. Zollo

Affiliation Department of Biochemistry, University of Yaoundé, Yaoundé, Cameroon

Nada Abla

Affiliation Medicines for Malaria Venture, Geneva, Switzerland

Benjamin Blasco

Affiliation Medicines for Malaria Venture, Geneva, Switzerland

Jeremy Burrows

Affiliation Medicines for Malaria Venture, Geneva, Switzerland

Benoît Laleu

Affiliation Medicines for Malaria Venture, Geneva, Switzerland

Didier Leroy

Affiliation Medicines for Malaria Venture, Geneva, Switzerland

Thomas Spangenberg

Current address: Global Health, Merck, Coinsins, Switzerland

Affiliation Medicines for Malaria Venture, Geneva, Switzerland

Timothy Wells

Affiliation Medicines for Malaria Venture, Geneva, Switzerland

Paul A. Willis

Affiliation Medicines for Malaria Venture, Geneva, Switzerland

Competing Interests

The following commercial organizations employ or employed some of the authors, which might be considered a conflict of interest by some readers: BBD BioPhenix SL—BIOBIDE: Aintzane Alday PhD, Ainhoa Alzualde PhD, and, Arantza Muriana; Celia Quevedo PhD; SCYNEXIS, Inc.: Tana Bowling, Audrey Burton, Luke Mercer, and, Bakela Nare PhD; GlaxoSmithKline: Francisco Javier Gamo, PhD, Maria Jose Lafuente, PhD, and Sarah Prats; Eisai Co., Ltd.: Takaaki Horii Ph.D. and Nao-aki Watanabe Ph.D.; Novartis Inc.: Mark Baker PhD MSc (med), and David M. Plouffe; Definiens AG: Andreas Spitzmüller PhD; and, Merck Serono Inc: Thomas Spangenberg PhD.

Author Contributions

Conceived and designed the experiments: WCVV JHA MHA PA AAlz KTA SVA VMA LA MBa SBa CBM SBh QB LB JBo LEB FFB MBr CRC DC MBC GJC SD’A MD JLD SDu MTF JAFR DAF IF FJG BG TG RKG KKH AH TH PH CH II LTJ AK JK SKic KK DEK SLa ML LMa DM NRM SMa SMc SMe JMe RNM JPM BN CN KKO SAP RJQ RSO RSF NGR FS RSi DAS TSo WS YS SJS DTa DTh KFT ST AKT VT JMV AFW EAW EW JBu TSp TW PAW. Performed the experiments: RA VA PA AAld YAR AAls AAlz KTA LA QB TB JBr AB CRC GC MC DC MBC KCCC WC AC BLC DDCL YC GJC NC SD’A MD AYD SDu SAESES IF PVTF AG SG BG GMG RG WAG NG KKH PH TBH KIS MAI AJ ANJ AK TK SKic SKim VPK MJL SLe AML FL DLi LLi MIL AL LLu IL DM NRM SMa SMc IMV SMe LMe ANM FMRdC JMü SNH NN SN KKO DO GPan SPa KP NP SPr DMP SAP AP CQ CAR MAR AR JS NGR MS FSV FS AS SMS SS BMS YS LRYT AT ST AKT VT KOU IU CV EV PVV HV NW KW PMW MW WW NY. Analyzed the data: WCVV JHA RA VA MHA PA AAld YAR AAls AAlz KTA SVA VMA LA MBa SBa CBM SBh QB LB TB JBo LEB FFB JBr MBr AB CRC GC MC DC MBC KCCC WC AC BLC DDCL YC GJC NC SD’A NLD MD JLD AYD SDu SAESES MTF JAFR DAF IF PVTF AG FJG SG BG TG GMG RG WAG NG RKG MAEH KKH AH RHvH TH PH TBH CH II KIS MAI AJ ANJ LTJ RHYJ AK JK TK SKic SKim KK VPK DEK MJL SLa NL SLe AML FL DLi LLi ML MIL AL LLu IL LMa DM NRM SMa SMc IMV SMe LMe JMe ANM RNM FMRdC SMo JPM JMü AM SNH BN CN NN SN KKO DO GPan GPap SPa KP NP SPr DMP SAP AP CQ RJQ CAR MAR AR RSO RSF JS NGR US MS FSV FS RSi DAS TSo AS SMS DJS WS SS BMS YS SJS DTa LRYT AT DTh KFT ST AKT VT KOU IU CV EV JMV PVV HV NW KW PMW AFW EAW EW MW WW NY PHAZ NA BB JBu BL DLe TSp TW PAW. Contributed reagents/materials/analysis tools: AYD. Wrote the paper: WCVV JHA RA VA MHA PA AAld YAR AAls AAlz KTA SVA VMA LA MBa SBa CBM SBh QB LB TB JBo LEB FFB JBr MBr AB CRC GC MC DC MBC KCCC WC AC BLC DDCL YC GJC NC SD’A NLD MD JLD AYD SDu SAESES MTF JAFR DAF IF PVTF AG FJG SG BG TG GMG RG WAG NG RKG MAEH KKH AH RHvH TH PH TBH CH II KIS MAI AJ ANJ LTJ RHYJ AK JK TK SKic SKim KK VPK DEK MJL SLa NL SLe AML FL DLi LLi ML MIL AL LLu IL LMa DM NRM SMa SMc IMV SMe LMe JMe ANM RNM FMRdC SMo JPM JMü AM SNH BN CN NN SN KKO DO GPan GPap SPa KP NP SPr DMP SAP AP CQ RJQ CAR MAR AR RSO RSF JS NGR US MS FSV FS RSi DAS TSo AS SMS DJS WS SS BMS YS SJS DTa LRYT AT DTh KFT ST AKT VT KOU IU CV EV JMV PVV HV NW KW PMW AFW EAW EW MW WW NY PHAZ NA BB JBu BL DLe TSp TW PAW.