Post-Transcriptional Regulation of KLF4 by High-Risk Human Papillomaviruses Is Necessary for the Differentiation-Dependent Viral Life Cycle

Vignesh Kumar Gunasekharan; Yan Li; Jorge Andrade; Laimonis A. Laimins

doi:10.1371/journal.ppat.1005747

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Open Access

Peer-reviewed

Research Article

Post-Transcriptional Regulation of KLF4 by High-Risk Human Papillomaviruses Is Necessary for the Differentiation-Dependent Viral Life Cycle

Vignesh Kumar Gunasekharan,

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Yan Li,

Affiliation Center for Research Informatics, The University of Chicago, Chicago, Illinois, United States of America
⨯
Jorge Andrade,

Affiliation Center for Research Informatics, The University of Chicago, Chicago, Illinois, United States of America

http://orcid.org/0000-0003-3210-2186

⨯
Laimonis A. Laimins

* E-mail: l-laimins@northwestern.edu

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯

Post-Transcriptional Regulation of KLF4 by High-Risk Human Papillomaviruses Is Necessary for the Differentiation-Dependent Viral Life Cycle

Vignesh Kumar Gunasekharan,
Yan Li,
Jorge Andrade,
Laimonis A. Laimins

Published: July 7, 2016
https://doi.org/10.1371/journal.ppat.1005747

About the Authors

Vignesh Kumar Gunasekharan

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

Yan Li

Affiliation Center for Research Informatics, The University of Chicago, Chicago, Illinois, United States of America

Jorge Andrade

Affiliation Center for Research Informatics, The University of Chicago, Chicago, Illinois, United States of America

http://orcid.org/0000-0003-3210-2186

Laimonis A. Laimins

* E-mail: l-laimins@northwestern.edu

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LAL VKG. Performed the experiments: VKG YL JA. Analyzed the data: LAL VKG YL JA. Contributed reagents/materials/analysis tools: VKG. Wrote the paper: LAL VKG.

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Cell differentiation
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Keratinocytes
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Gene expression
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HPV-31
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Immunoprecipitation
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Phosphorylation
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Life cycles
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Human papillomavirus infection
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