About the Authors

Ning Chai

ningc@gene.com (NC); mant@gene.com (MWT)

Affiliation Infectious Diseases Department, Genentech, South San Francisco, California, United States of America

Lee R. Swem

Current address: Therapeutic Antibody Department, Achaogen, South San Francisco, California, United States of America

Affiliation Infectious Diseases Department, Genentech, South San Francisco, California, United States of America

Mike Reichelt

Affiliation Pathology Department, Genentech, South San Francisco, California, United States of America

Haiyin Chen-Harris

Affiliations Bioinformatics & Computational Biology Department, Genentech, South San Francisco, California, United States of America, Cancer Immunology Department, Genentech, South San Francisco, California, United States of America

Elizabeth Luis

Affiliation Protein Chemistry Department, Genentech, South San Francisco, California, United States of America

Summer Park

Affiliation Translational Immunology Department, Genentech, South San Francisco, California, United States of America

Ashley Fouts

Affiliation Infectious Diseases Department, Genentech, South San Francisco, California, United States of America

Patrick Lupardus

Affiliation Structural Biology Department, Genentech, South San Francisco, California, United States of America

Thomas D. Wu

Affiliation Bioinformatics & Computational Biology Department, Genentech, South San Francisco, California, United States of America

Olga Li

Affiliation Development Sciences Department, Genentech, South San Francisco, California, United States of America

Jacqueline McBride

Affiliation Development Sciences Department, Genentech, South San Francisco, California, United States of America

Michael Lawrence

Affiliation Bioinformatics & Computational Biology Department, Genentech, South San Francisco, California, United States of America

Min Xu

Affiliation Translational Immunology Department, Genentech, South San Francisco, California, United States of America

Man-Wah Tan

ningc@gene.com (NC); mant@gene.com (MWT)

Affiliation Infectious Diseases Department, Genentech, South San Francisco, California, United States of America

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: NC, MR, EL, AF, PL, and MWT are employees of Genentech; LRS is an employee of Achaogen. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NC LRS MWT. Performed the experiments: NC MR EL SP AF OL. Analyzed the data: NC LRS MWT HCH TDW ML. Contributed reagents/materials/analysis tools: PL JM MX. Wrote the paper: NC MWT.