African Swine Fever Virus Undergoes Outer Envelope Disruption, Capsid Disassembly and Inner Envelope Fusion before Core Release from Multivesicular Endosomes

Bruno Hernáez; Milagros Guerra; María L. Salas; Germán Andrés

doi:10.1371/journal.ppat.1005595

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Peer-reviewed

Research Article

African Swine Fever Virus Undergoes Outer Envelope Disruption, Capsid Disassembly and Inner Envelope Fusion before Core Release from Multivesicular Endosomes

Bruno Hernáez,

Affiliation Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain
⨯
Milagros Guerra,

Affiliation Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain
⨯
María L. Salas,

Affiliation Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain
⨯
Germán Andrés

* E-mail: gandres@cbm.csic.es

Affiliation Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain

http://orcid.org/0000-0003-0265-5409

⨯

African Swine Fever Virus Undergoes Outer Envelope Disruption, Capsid Disassembly and Inner Envelope Fusion before Core Release from Multivesicular Endosomes

Bruno Hernáez,
Milagros Guerra,
María L. Salas,
Germán Andrés

Published: April 25, 2016
https://doi.org/10.1371/journal.ppat.1005595

About the Authors

Bruno Hernáez

Affiliation Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain

Milagros Guerra

Affiliation Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain

María L. Salas

Affiliation Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain

Germán Andrés

* E-mail: gandres@cbm.csic.es

Affiliation Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain

http://orcid.org/0000-0003-0265-5409

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BH GA. Performed the experiments: BH MG GA. Analyzed the data: BH GA. Contributed reagents/materials/analysis tools: MLS. Wrote the paper: GA.

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Endosomes
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Macrophages
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Vesicles
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Viral packaging
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Viral core
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Swine
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Cell membranes
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Virions
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