About the Authors

Laurence H. Arnold

Contributed equally to this work with: Laurence H. Arnold, Harriet C. T. Groom

Affiliation The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

Harriet C. T. Groom

Contributed equally to this work with: Laurence H. Arnold, Harriet C. T. Groom

Affiliation The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

Simone Kunzelmann

Affiliation The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

David Schwefel

Affiliation The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

Sarah J. Caswell

Affiliation The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

Paula Ordonez

Affiliation The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

Melanie C. Mann

Affiliation The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

Sabrina Rueschenbaum

Affiliation The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

David C. Goldstone

Current address: School of Biological Sciences, University of Auckland, Auckland, New Zealand

Affiliation The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

Simon Pennell

Affiliation The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

Steven A. Howell

Affiliation The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

Jonathan P. Stoye

Affiliations The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom, Faculty of Medicine, Imperial College London, London, United Kingdom

Michelle Webb

Affiliation Centre for Genomic Medicine, Institute for Human Development, Faculty of Medicine and Human Sciences, University of Manchester, Manchester, United Kingdom

Ian A. Taylor

Ian.Taylor@crick.ac.uk (IAT); Kate.Bishop@crick.ac.uk (KNB)

Affiliation The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

Kate N. Bishop

Ian.Taylor@crick.ac.uk (IAT); Kate.Bishop@crick.ac.uk (KNB)

Affiliation The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LHA HCTG SK DS PO DCG SP JPS MW IAT KNB. Performed the experiments: LHA HCTG SK DS SJC PO MCM SR DCG SAH MW IAT. Analyzed the data: LHA HCTG SK DS SJC PO DCG MW IAT KNB. Wrote the paper: LHA HCTG SK DS JPS MW IAT KNB.