The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes

Erika S. Langsfeld; Jason M. Bodily; Laimonis A. Laimins

doi:10.1371/journal.ppat.1005181

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Open Access

Peer-reviewed

Research Article

The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes

Erika S. Langsfeld,

Affiliation Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯
Jason M. Bodily,

Affiliation Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Laimonis A. Laimins

* E-mail: l-laimins@northwestern.edu

Affiliation Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States of America
⨯

The Deacetylase Sirtuin 1 Regulates Human Papillomavirus Replication by Modulating Histone Acetylation and Recruitment of DNA Damage Factors NBS1 and Rad51 to Viral Genomes

Erika S. Langsfeld,
Jason M. Bodily,
Laimonis A. Laimins

Published: September 25, 2015
https://doi.org/10.1371/journal.ppat.1005181

About the Authors

Erika S. Langsfeld

Affiliation Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States of America

Jason M. Bodily

Affiliation Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America

Laimonis A. Laimins

* E-mail: l-laimins@northwestern.edu

Affiliation Department of Microbiology-Immunology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ESL LAL. Performed the experiments: ESL. Analyzed the data: ESL JMB LAL. Contributed reagents/materials/analysis tools: ESL JMB. Wrote the paper: ESL LAL.

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Cell differentiation
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Human papillomavirus
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HPV-31
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DNA damage
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Genomics
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Histones
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Functional genomics
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Viral replication
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