Intracellular Survival of Leishmania major Depends on Uptake and Degradation of Extracellular Matrix Glycosaminoglycans by Macrophages

Thomas Naderer; Joanne Heng; Eleanor C. Saunders; Joachim Kloehn; Thusitha W. Rupasinghe; Tracey J. Brown; Malcolm J. McConville

doi:10.1371/journal.ppat.1005136

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Open Access

Peer-reviewed

Research Article

Intracellular Survival of Leishmania major Depends on Uptake and Degradation of Extracellular Matrix Glycosaminoglycans by Macrophages

Thomas Naderer ,

Contributed equally to this work with: Thomas Naderer, Joanne Heng

* E-mail: Thomas.naderer@monash.edu (TN); malcolmm@unimelb.edu.au (MJM)

Affiliations The Department of Biochemistry and Molecular Biology and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
⨯
Joanne Heng ,

Contributed equally to this work with: Thomas Naderer, Joanne Heng

Affiliation The Department of Biochemistry and Molecular Biology and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia
⨯
Eleanor C. Saunders,

Affiliation The Department of Biochemistry and Molecular Biology and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia
⨯
Joachim Kloehn,

Affiliation The Department of Biochemistry and Molecular Biology and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia
⨯
Thusitha W. Rupasinghe,

Affiliation Metabolomics Australia, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia
⨯
Tracey J. Brown,

Affiliation Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
⨯
Malcolm J. McConville

* E-mail: Thomas.naderer@monash.edu (TN); malcolmm@unimelb.edu.au (MJM)

Affiliation The Department of Biochemistry and Molecular Biology and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia
⨯

Intracellular Survival of Leishmania major Depends on Uptake and Degradation of Extracellular Matrix Glycosaminoglycans by Macrophages

Thomas Naderer,
Joanne Heng,
Eleanor C. Saunders,
Joachim Kloehn,
Thusitha W. Rupasinghe,
Tracey J. Brown,
Malcolm J. McConville

Published: September 3, 2015
https://doi.org/10.1371/journal.ppat.1005136

About the Authors

Thomas Naderer

Contributed equally to this work with: Thomas Naderer, Joanne Heng

* E-mail: Thomas.naderer@monash.edu (TN); malcolmm@unimelb.edu.au (MJM)

Affiliations The Department of Biochemistry and Molecular Biology and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia, Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

Joanne Heng

Contributed equally to this work with: Thomas Naderer, Joanne Heng

Affiliation The Department of Biochemistry and Molecular Biology and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia

Eleanor C. Saunders

Affiliation The Department of Biochemistry and Molecular Biology and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia

Joachim Kloehn

Affiliation The Department of Biochemistry and Molecular Biology and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia

Thusitha W. Rupasinghe

Affiliation Metabolomics Australia, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia

Tracey J. Brown

Affiliation Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia

Malcolm J. McConville

* E-mail: Thomas.naderer@monash.edu (TN); malcolmm@unimelb.edu.au (MJM)

Affiliation The Department of Biochemistry and Molecular Biology and the Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Victoria, Australia

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TN JH MJM. Performed the experiments: TN JH ECS JK TWR. Analyzed the data: TN JH ECS JK MJM. Contributed reagents/materials/analysis tools: TJB. Wrote the paper: TN JH ECS JK TWR TJB MJM.

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Macrophages
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Promastigotes
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Parasitic diseases
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Amastigotes
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Leishmania
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Lesions
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Body weight
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Chitin
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