About the Authors

Simon P. Fletcher

Current address: Gilead Sciences, Foster City, California, United States of America

Affiliation Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America

Daniel J. Chin

Current address: Quanticel Pharmaceuticals, San Francisco, California, United States of America

Affiliation Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America

Lore Gruenbaum

Current address: Roche Pharma Research & Early Development, Roche Innovation Center New York, New York, New York, United States of America

Affiliation Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America

Hans Bitter

Current address: Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States of America

Affiliation Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America

Erik Rasmussen

Current address: Regeneron Pharmaceuticals, Tarrytown, New York, United States of America

Affiliation Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America

Palanikumar Ravindran

Current address: Bristol-Myers Squibb Company, Princeton, New Jersey, United States of America

Affiliation Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America

David C. Swinney

Current address: iRND3, Institute for Rare and Neglected Diseases Drug Discovery, Mountain View, California, United States of America

Affiliation Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America

Fabian Birzele

Affiliation Roche Pharma Research & Early Development, Roche Innovation Center Penzberg, Penzberg, Germany

Roland Schmucki

Affiliation Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland

Stefan H. Lorenz

Affiliation Roche Pharma Research & Early Development, Roche Innovation Center Penzberg, Penzberg, Germany

Erhard Kopetzki

Affiliation Roche Pharma Research & Early Development, Roche Innovation Center Penzberg, Penzberg, Germany

Jade Carter

Current address: New York Genome Center, New York, New York, United States of America

Affiliation Pharma Research & Early Development, Hoffmann-La Roche, Inc., Nutley, New Jersey, United States of America

Miriam Triyatni

Affiliation Roche Pharma Research & Early Development, Roche Innovation Center Basel, Basel, Switzerland

Linta M. Thampi

Affiliation Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, United States of America

Junming Yang

Affiliation Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, United States of America

Dalal AlDeghaither

Affiliation Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, United States of America

Marta G. Murredu

Affiliation Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, United States of America

Paul Cote

Affiliation Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, United States of America

Stephan Menne

sm923@georgetown.edu

Affiliation Department of Microbiology & Immunology, Georgetown University Medical Center, Washington, District of Columbia, United States of America

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: SPF, DJC, LG, HB, ER, PR, DCS, FB, RS, SHL, EK, JC, MT are/were employees of Hoffmann-La Roche, Inc. (http://www.roche.com/index.htm). This does not alter our adherence to all PLOS policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SPF DCS SM. Performed the experiments: SM PC LMT JY DA MGM JC. Analyzed the data: SPF SM RS FB PR DJC ER MT HB LG. Contributed reagents/materials/analysis tools: SHL EK. Wrote the paper: SPF SM.