About the Authors

Ad de Groof

ad.de.groof@merck.com (AdG); c.m.vanderhoek@amc.uva.nl (LvdH)

Affiliation MSD Animal Health / Intervet International bv., Department Discovery & Technology, Boxmeer, The Netherlands

Lars Guelen

Affiliation MSD Animal Health / Intervet International bv., Department Discovery & Technology, Boxmeer, The Netherlands

Martin Deijs

Affiliation Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Yorick van der Wal

Affiliation MSD Animal Health / Intervet International bv., Department Discovery & Technology, Boxmeer, The Netherlands

Masato Miyata

Current address: Technology Development, School of Applied Science, Temasek Polytechnic, Singapore

Affiliation MSD Animal Health Innovation Pte Ltd, Singapore

Kah Sing Ng

Affiliation MSD Animal Health Innovation Pte Ltd, Singapore

Lotte van Grinsven

Affiliation MSD Animal Health / Intervet International bv., Department Discovery & Technology, Boxmeer, The Netherlands

Bartjan Simmelink

Affiliation MSD Animal Health / Intervet International bv., Department Discovery & Technology, Boxmeer, The Netherlands

Yvonne Biermann

Affiliation MSD Animal Health / Intervet International bv., Department Discovery & Technology, Boxmeer, The Netherlands

Luc Grisez

Affiliation MSD Animal Health / Intervet International bv., Department Discovery & Technology, Boxmeer, The Netherlands

Jan van Lent

Affiliation Laboratory of Virology and Wageningen Electron Microscopy Centre, Wageningen University, Wageningen, The Netherlands

Anthony de Ronde

Affiliation Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Siow Foong Chang

Affiliation MSD Animal Health Innovation Pte Ltd, Singapore

Carla Schrier

Current address: Vaxxinova GmbH, Münster, Germany

‡ These authors contributed equally to this work and share last authorship.

Affiliation MSD Animal Health / Intervet International bv., Department Discovery & Technology, Boxmeer, The Netherlands

Lia van der Hoek

ad.de.groof@merck.com (AdG); c.m.vanderhoek@amc.uva.nl (LvdH)

‡ These authors contributed equally to this work and share last authorship.

Affiliation Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: AdG, LGu, MM, KSN, LvG, BS, YB, LGr, SFC, and CS are or have been employed at MSD Animal Health, a commercial company. MD, LvdH, LGu, AdG, CS, LGr, SFC, MM, and KSN are inventors on a patent application describing vaccines, diagnostics and antibodies on the basis of SDDV (WO 2014/191445 A1). LvdH is a consultant for MSD Animal Health. This does not alter our adherence to all PLOS policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: AdG LGu LGr CS LvdH. Performed the experiments: AdG LGu MD YvdW KSN LvG BS YB JvL MM. Analyzed the data: AdG LGu MD AdR LGr JvL MM CS SFC LvdH. Contributed reagents/materials/analysis tools: MM KSN SFC LGr. Wrote the paper: AdG LvdH. Carried out and coordinated sample collection and processing from field outbreaks: MM KSN LGr SFC. Performed VIDISCA analysis and bioinformatics analyses: MD LvdH. Set up and performed PCR analyses: LGu MD YvdW LvG LvdH. DNA sequencing, genome walking and genome alignments: MD LvdH. ORF assignments: AdR MD. Phylogenic analyses: LGu MD. Virus culture, virus titration, and virus inactivation: AdG YvdW LvG YB. Accomplished recombinant protein expression: BS. Electron microscopy: JvL. Virus challenge to fish and vaccination challenge studies: MM KSN SFC. Supervised the study: CS LvdH.