About the Authors

Shilpi Khare

Affiliation Department of Genetics and Neglected Diseases, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

Steven L. Roach

Current Address: Dart NeuroScience, San Diego, California, United States of America

Affiliation Department of Medicinal Chemistry, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

S. Whitney Barnes

Affiliation Department of Genetics and Neglected Diseases, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

Dominic Hoepfner

Affiliation Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland

John R. Walker

Affiliation Department of Genetics and Neglected Diseases, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

Arnab K. Chatterjee

Current Address: California Institute for Biomedical Research (Calibr), La Jolla, California, United States of America

Affiliation Department of Medicinal Chemistry, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

R. Jeffrey Neitz

Affiliation Small Molecule Discovery Center and Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

Michelle R. Arkin

Affiliation Small Molecule Discovery Center and Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, United States of America

Case W. McNamara

Current Address: California Institute for Biomedical Research (Calibr), La Jolla, California, United States of America

Affiliation Department of Genetics and Neglected Diseases, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

Jaime Ballard

Affiliation Department of Genetics and Neglected Diseases, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

Yin Lai

Affiliation Department of Genetics and Neglected Diseases, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

Yue Fu

Affiliation Department of Genetics and Neglected Diseases, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

Valentina Molteni

Affiliation Department of Medicinal Chemistry, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

Vince Yeh

Affiliation Department of Medicinal Chemistry, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

James H. McKerrow

Affiliation Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, United States of America

Richard J. Glynne

Affiliation Department of Genetics and Neglected Diseases, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

Frantisek Supek

fsupek@gnf.org

Affiliation Department of Genetics and Neglected Diseases, Genomics Institute of the Novartis Research Foundation, San Diego, California, United States of America

Competing Interests

I have read the journal's policy and the authors of this manuscript have the following competing interests: SK, SWB, DH, JRW, JB, YL, YF, VM, VY, RJG, and FS are employed at Novartis, a commercial company. This does not alter our adherence to all PLOS Pathogens policies on sharing data and materials. SLR, AKC, RJN, MRA, CWM and JHM have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SK SLR SWB DH JRW AKC RJN MRA CWM YF VM VY JHM RJG FS. Performed the experiments: SK SLR SWB DH JB YL YF. Analyzed the data: SK SWB DH JRW AKC RJN MRA CWM JB YL YF RJG FS. Contributed reagents/materials/analysis tools: SLR JRW RJN CWM. Wrote the paper: SK DH MRA CWM VM VY JHM RJG FS.