BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses

Dipanjan Dutta; Sujoy Dutta; Mohanan Valiya Veettil; Arunava Roy; Mairaj Ahmed Ansari; Jawed Iqbal; Leela Chikoti; Binod Kumar; Karen E. Johnson; Bala Chandran

doi:10.1371/journal.ppat.1005030

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Peer-reviewed

Research Article

BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses

Dipanjan Dutta ,

Contributed equally to this work with: Dipanjan Dutta, Sujoy Dutta

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Sujoy Dutta ,

Contributed equally to this work with: Dipanjan Dutta, Sujoy Dutta

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Mohanan Valiya Veettil,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Arunava Roy,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Mairaj Ahmed Ansari,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Jawed Iqbal,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Leela Chikoti,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Binod Kumar,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Karen E. Johnson,

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯
Bala Chandran

* E-mail: bala.chandran@rosalindfranklin.edu

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America
⨯

BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses

Dipanjan Dutta,
Sujoy Dutta,
Mohanan Valiya Veettil,
Arunava Roy,
Mairaj Ahmed Ansari,
Jawed Iqbal,
Leela Chikoti,
Binod Kumar,
Karen E. Johnson,
Bala Chandran

Published: June 29, 2015
https://doi.org/10.1371/journal.ppat.1005030

About the Authors

Dipanjan Dutta

Contributed equally to this work with: Dipanjan Dutta, Sujoy Dutta

Affiliation H. M. Bligh Cancer Research Laboratories, Department of Microbiology and Immunology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America

Sujoy Dutta

Contributed equally to this work with: Dipanjan Dutta, Sujoy Dutta

Mohanan Valiya Veettil

Arunava Roy

Mairaj Ahmed Ansari

Jawed Iqbal

Leela Chikoti

Binod Kumar

Karen E. Johnson

Bala Chandran

* E-mail: bala.chandran@rosalindfranklin.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DD SD BC. Performed the experiments: DD SD MVV AR MAA JI LC BK KEJ. Analyzed the data: DD SD BC. Wrote the paper: DD SD BC.

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Inflammasomes
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Cytoplasm
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Genetic causes of cancer
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Immunoprecipitation
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Mammalian genomics
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Viral genomics
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Viral genome
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Kaposi's sarcoma-associated herpesvirus
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