About the Authors
- Joy Ogbechi
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Affiliation Department of Microbial and Cellular Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom
- Marie-Thérèse Ruf
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Affiliations Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
- Belinda S. Hall
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Affiliation Department of Microbial and Cellular Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom
- Katherine Bodman-Smith
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Affiliation Department of Microbial and Cellular Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom
- Moritz Vogel
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Affiliation Section Clinical Tropical Medicine, Heidelberg University Hospital, Heidelberg, Germany
- Hua-Lin Wu
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Affiliation Department of Biochemistry and Molecular Biology, National Cheng Kung University, Tainan, Taiwan
- Alexander Stainer
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Affiliation Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Reading, United Kingdom
- Charles T. Esmon
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Affiliation Coagulation Biology Laboratory, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States of America
- Josefin Ahnström
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Affiliation Centre for Haematology, Faculty of Medicine, Imperial College London, London, United Kingdom
- Gerd Pluschke
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Affiliations Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
- Rachel E. Simmonds
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* E-mail: rachel.simmonds@surrey.ac.uk
Affiliation Department of Microbial and Cellular Sciences, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, United Kingdom
Competing Interests
I have read the journal's policy and the authors of this manuscript have the following competing interests: The Oklahoma Medical Research Foundation has patents granted to CTE and licenses for the isolation of protein C and the use of aPC in the treatment dysfunctional endothelium. This does not alter our adherence to all PLOS policies on sharing data and materials. The remaining authors have declared that no competing interests exist.
Author Contributions
Conceived and designed the experiments: JO MTR BSH AS CTE JA GP RES. Performed the experiments: JO MTR BSH AS JA RES. Analyzed the data: JO MTR BSH CTE JA GP RES. Contributed reagents/materials/analysis tools: HLW CTE KBS MV AS JA GP RES. Wrote the paper: JO MTR BSH KBS MV HLW CTE JA GP RES. Coordinated the clinical research: MV.