About the Authors

Ema T. Crooks

Affiliation San Diego Biomedical Research Institute, San Diego, California, United States of America

Tommy Tong

Affiliation San Diego Biomedical Research Institute, San Diego, California, United States of America

Bimal Chakrabarti

Current address: International AIDS Vaccine Initiative HIV Vaccine Design Program, Translational Health Science and Technology Institute, Haryana, India

Affiliation International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center at The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, United States of America

Kristin Narayan

Current address: Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, United States of America

Affiliation Altravax, Inc., Sunnyvale, California, United States of America

Ivelin S. Georgiev

Affiliation Vaccine Research Center, National Institutes of Health (NIH), Bethesda, Maryland, United States of America

Sergey Menis

Affiliations International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center at The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, United States of America, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America

Xiaoxing Huang

Affiliation National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing, China

Daniel Kulp

Affiliations International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center at The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, United States of America, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America

Keiko Osawa

Affiliation San Diego Biomedical Research Institute, San Diego, California, United States of America

Janelle Muranaka

Affiliation Altravax, Inc., Sunnyvale, California, United States of America

Guillaume Stewart-Jones

Affiliations Vaccine Research Center, National Institutes of Health (NIH), Bethesda, Maryland, United States of America, MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, The John Radcliffe Hospital, Oxford, United Kingdom

Joanne Destefano

Affiliation International AIDS Vaccine Initiative, Design and Development Laboratory, Brooklyn, New York, United States of America

Sijy O’Dell

Affiliation Vaccine Research Center, National Institutes of Health (NIH), Bethesda, Maryland, United States of America

Celia LaBranche

Affiliation Department of Surgery, Duke University, Duke University Medical Center, Durham, North Carolina, United States of America

James E. Robinson

Affiliation Tulane National Primate Research Center, Covington, Louisiana, United States of America

David C. Montefiori

Affiliation Department of Surgery, Duke University, Duke University Medical Center, Durham, North Carolina, United States of America

Krisha McKee

Affiliation Vaccine Research Center, National Institutes of Health (NIH), Bethesda, Maryland, United States of America

Sean X. Du

Affiliation Altravax, Inc., Sunnyvale, California, United States of America

Nicole Doria-Rose

Affiliation Vaccine Research Center, National Institutes of Health (NIH), Bethesda, Maryland, United States of America

Peter D. Kwong

Affiliation Vaccine Research Center, National Institutes of Health (NIH), Bethesda, Maryland, United States of America

John R. Mascola

Affiliation Vaccine Research Center, National Institutes of Health (NIH), Bethesda, Maryland, United States of America

Ping Zhu

Affiliation National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Chaoyang District, Beijing, China

William R. Schief

Affiliations International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center at The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, United States of America, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America, Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts, United States of America

Richard T. Wyatt

Affiliations International AIDS Vaccine Initiative (IAVI) Neutralizing Antibody Center at The Scripps Research Institute, Department of Immunology and Microbial Science, La Jolla, California, United States of America, Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery, The Scripps Research Institute, La Jolla, California, United States of America

Robert G. Whalen

Affiliation Altravax, Inc., Sunnyvale, California, United States of America

James M. Binley

jbinley@sdbri.org

Affiliation San Diego Biomedical Research Institute, San Diego, California, United States of America

Competing Interests

The authors have declared that no competing interests exist. Some authors are employed with Altravax Inc, but this does not affect competing interests. No employment, consultancies, patents or products in development or on market represent a competing interest with this article. This does not alter our adherence to all PLOS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ETC TT JMB ISG GSJ JD PZ RTW RGW. Performed the experiments: ETC TT BC KN JM SO CL DCM KM XH KO. Analyzed the data: ETC TT JMB ISG JM SO CL JER DCM KM SXD NDR PDK JRM PZ RGW SM DK KO. Contributed reagents/materials/analysis tools: KN ISG JM JD JER KM SXD NDR WRS RTW RGW SM DK. Wrote the paper: TT JMB GSJ PDK JRM PZ WRS RTW SM DK.