The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction

Leanne Mortimer; France Moreau; Steve Cornick; Kris Chadee

doi:10.1371/journal.ppat.1004887

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Open Access

Peer-reviewed

Research Article

The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction

Leanne Mortimer,

Affiliation Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
⨯
France Moreau,

Affiliation Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
⨯
Steve Cornick,

Affiliation Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
⨯
Kris Chadee

* E-mail: kchadee@ucalgary.ca

Affiliation Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
⨯

The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction

Leanne Mortimer,
France Moreau,
Steve Cornick,
Kris Chadee

Published: May 8, 2015
https://doi.org/10.1371/journal.ppat.1004887

About the Authors

Leanne Mortimer

Affiliation Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada

France Moreau

Affiliation Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada

Steve Cornick

Affiliation Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada

Kris Chadee

* E-mail: kchadee@ucalgary.ca

Affiliation Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada

Competing Interests

The authors have declared that no competing interests exist

Author Contributions

Conceived and designed the experiments: LM KC. Performed the experiments: LM FM SC. Analyzed the data: LM FM SC. Contributed reagents/materials/analysis tools: LM FM SC. Wrote the paper: LM KC.

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Integrins
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Inflammasomes
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Macrophages
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Enzyme assays
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Phosphorylation
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Colon
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Cysteine proteases
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Entamoeba histolytica
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