About the Authors

Ihssane Bouybayoune

‡ These authors share first authorship on this work.

Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy

Susanna Mantovani

Present address: School of Biomedical Sciences, The University of Queensland, Brisbane, Australia

‡ These authors share first authorship on this work.

Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy

Federico Del Gallo

Present address: Department of Neurological and Movement Sciences, University of Verona, Verona, Italy

‡ These authors share first authorship on this work.

Affiliation Department of Health Sciences, University of Milan Medical School, Milan, Italy

Ilaria Bertani

Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy

Elena Restelli

Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy

Liliana Comerio

Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy

Laura Tapella

Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy

Francesca Baracchi

Affiliation Department of Health Sciences, University of Milan Medical School, Milan, Italy

Natalia Fernández-Borges

Affiliation CIC bioGUNE, Parque Tecnológico de Bizkaia, Derio, Spain

Michela Mangieri

Present address: Department of Neuropathology, Golgi Cenci Foundation, Abbiategrasso (MI), Italy

Affiliation Division of Neuropathology and Neurology, IRCCS Foundation “Carlo Besta” National Neurological Institute, Milan, Italy

Cinzia Bisighini

Affiliation Bio-Imaging Unit, Department of Cardiovascular Research, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy

Galina V. Beznoussenko

Affiliation IFOM—FIRC Institute of Molecular Oncology, Milan, Italy

Alessandra Paladini

Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy

Claudia Balducci

Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy

Edoardo Micotti

Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy

Gianluigi Forloni

Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy

Joaquín Castilla

Affiliations CIC bioGUNE, Parque Tecnológico de Bizkaia, Derio, Spain, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain

Fabio Fiordaliso

Affiliation Bio-Imaging Unit, Department of Cardiovascular Research, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy

Fabrizio Tagliavini

Affiliation Division of Neuropathology and Neurology, IRCCS Foundation “Carlo Besta” National Neurological Institute, Milan, Italy

Luca Imeri

Affiliation Department of Health Sciences, University of Milan Medical School, Milan, Italy

Roberto Chiesa

roberto.chiesa@marionegri.it

Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JC FT LI RC. Performed the experiments: IBo SM FDG IBe ER LC LT FB NFB MM CB GVB AP CB EM FF. Analyzed the data: IBo SM FDG IBe ER LC LT FB NFB MM CB GVB AP CB EM GF JC FF FT LI RC. Wrote the paper: FT LI RC.