Human Papillomaviruses Activate and Recruit SMC1 Cohesin Proteins for the Differentiation-Dependent Life Cycle through Association with CTCF Insulators

Kavi Mehta; Vignesh Gunasekharan; Ayano Satsuka; Laimonis A. Laimins

doi:10.1371/journal.ppat.1004763

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Open Access

Peer-reviewed

Research Article

Human Papillomaviruses Activate and Recruit SMC1 Cohesin Proteins for the Differentiation-Dependent Life Cycle through Association with CTCF Insulators

Kavi Mehta ,

Contributed equally to this work with: Kavi Mehta, Vignesh Gunasekharan

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Vignesh Gunasekharan ,

Contributed equally to this work with: Kavi Mehta, Vignesh Gunasekharan

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Ayano Satsuka,

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯
Laimonis A. Laimins

* E-mail: l-laimins@northwestern.edu

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯

Human Papillomaviruses Activate and Recruit SMC1 Cohesin Proteins for the Differentiation-Dependent Life Cycle through Association with CTCF Insulators

Kavi Mehta,
Vignesh Gunasekharan,
Ayano Satsuka,
Laimonis A. Laimins

Published: April 13, 2015
https://doi.org/10.1371/journal.ppat.1004763

About the Authors

Kavi Mehta

Contributed equally to this work with: Kavi Mehta, Vignesh Gunasekharan

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

Vignesh Gunasekharan

Contributed equally to this work with: Kavi Mehta, Vignesh Gunasekharan

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

Ayano Satsuka

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

Laimonis A. Laimins

* E-mail: l-laimins@northwestern.edu

Affiliation Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KM VG AS LAL. Performed the experiments: KM VG AS. Analyzed the data: KM VG AS LAL. Wrote the paper: KM VG LAL.

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Cell differentiation
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Genomics
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HPV-31
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Human papillomavirus
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Human papillomavirus infection
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Phosphorylation
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DNA damage
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Viral replication
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