About the Authors

Wan-Lin Yang

Contributed equally to this work with: Wan-Lin Yang, Roger D. Kouyos, Huldrych F. Günthard

Affiliations Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Institute of Medical Virology, University of Zurich, Zurich, Switzerland

Roger D. Kouyos

Contributed equally to this work with: Wan-Lin Yang, Roger D. Kouyos, Huldrych F. Günthard

Affiliations Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Institute of Medical Virology, University of Zurich, Zurich, Switzerland

Jürg Böni

Affiliation Institute of Medical Virology, University of Zurich, Zurich, Switzerland

Sabine Yerly

Affiliation Laboratory of Virology and AIDS Center, Geneva University Hospital, Geneva, Switzerland

Thomas Klimkait

Affiliation Department Biomedicine—Petersplatz, University of Basel, Basel, Switzerland

Vincent Aubert

Affiliation Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland

Alexandra U. Scherrer

Affiliations Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Institute of Medical Virology, University of Zurich, Zurich, Switzerland

Mohaned Shilaih

Affiliations Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Institute of Medical Virology, University of Zurich, Zurich, Switzerland

Trevor Hinkley

Affiliation Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland

Christos Petropoulos

Affiliation Monogram Biosciences, South San Francisco, California, United States of America

Sebastian Bonhoeffer

Affiliation Institute of Integrative Biology, ETH Zurich, Zurich, Switzerland

Huldrych F. Günthard

Contributed equally to this work with: Wan-Lin Yang, Roger D. Kouyos, Huldrych F. Günthard

huldrych.guenthard@usz.ch

Affiliations Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, Institute of Medical Virology, University of Zurich, Zurich, Switzerland

the Swiss HIV Cohort Study (SHCS)

Membership of the Swiss HIV Cohort Study (SHCS) is listed in the Acknowledgments.

Competing Interests

HFG has been an adviser and/or consultant for the following companies: GlaxoSmithKline, Abbott, Gilead, Novartis, Boehringer Ingelheim, Roche, Tibotec, Pfizer and Bristol-Myers Squibb, and has received unrestricted research and educational grants from Roche, Abbott, Bristol-Myers Squibb, Gilead, Astra-Zeneca, GlaxoSmithKline, and Merck Sharp & Dohme (all money went to institution). SY has been consultant for BMS, has received unrestricted research and educational grants from Roche, ViiV and Gilead. TK served as advisor for Bristol-Myers Squibb and Pfizer and has received travel support from Abbott and Pfizer. CP is an employee of Monogram Biosciences. This does not alter our adherence to all PLOS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: WLY RDK HFG. Performed the experiments: TH CP SB WLY RDK HFG. Analyzed the data: WLY RDK AUS HFG MS. Contributed reagents/materials/analysis tools: JB SY TK VA. Wrote the paper: WLY RDK HFG.