The Role of Misshapen NCK-related kinase (MINK), a Novel Ste20 Family Kinase, in the IRES-Mediated Protein Translation of Human Enterovirus 71

Shi Yun Leong; Bryan Kit Teck Ong; Justin Jang Hann Chu

doi:10.1371/journal.ppat.1004686

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Open Access

Peer-reviewed

Research Article

The Role of Misshapen NCK-related kinase (MINK), a Novel Ste20 Family Kinase, in the IRES-Mediated Protein Translation of Human Enterovirus 71

Shi Yun Leong,

Affiliation Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
⨯
Bryan Kit Teck Ong,

Affiliation Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
⨯
Justin Jang Hann Chu

* E-mail: miccjh@nus.edu.sg

Affiliation Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
⨯

The Role of Misshapen NCK-related kinase (MINK), a Novel Ste20 Family Kinase, in the IRES-Mediated Protein Translation of Human Enterovirus 71

Shi Yun Leong,
Bryan Kit Teck Ong,
Justin Jang Hann Chu

Published: March 6, 2015
https://doi.org/10.1371/journal.ppat.1004686

About the Authors

Shi Yun Leong

Affiliation Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Bryan Kit Teck Ong

Affiliation Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Justin Jang Hann Chu

* E-mail: miccjh@nus.edu.sg

Affiliation Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SYL BKTO JJHC. Performed the experiments: SYL BKTO JJHC. Analyzed the data: SYL BKTO JJHC. Contributed reagents/materials/analysis tools: SYL BKTO JJHC. Wrote the paper: SYL BKTO JJHC.

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Small interfering RNA
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MAPK signaling cascades
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Viral replication
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Protein translation
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Internal ribosome entry site
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Protein expression
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Transfection
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Phosphorylation
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