Uropathogenic Escherichia coli Superinfection Enhances the Severity of Mouse Bladder Infection

Drew J. Schwartz; Matt S. Conover; Thomas J. Hannan; Scott J. Hultgren

doi:10.1371/journal.ppat.1004599

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Open Access

Peer-reviewed

Research Article

Uropathogenic Escherichia coli Superinfection Enhances the Severity of Mouse Bladder Infection

Drew J. Schwartz,

Affiliation Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University in St. Louis, St. Louis, Missouri, United States of America
⨯
Matt S. Conover,

Affiliation Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University in St. Louis, St. Louis, Missouri, United States of America
⨯
Thomas J. Hannan,

Affiliation Department of Pathology & Immunology, Washington University in St. Louis, St. Louis, Missouri, United States of America
⨯
Scott J. Hultgren

* E-mail: Hultgren@wusm.wustl.edu

Affiliation Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University in St. Louis, St. Louis, Missouri, United States of America
⨯

Uropathogenic Escherichia coli Superinfection Enhances the Severity of Mouse Bladder Infection

Drew J. Schwartz,
Matt S. Conover,
Thomas J. Hannan,
Scott J. Hultgren

Published: January 8, 2015
https://doi.org/10.1371/journal.ppat.1004599

About the Authors

Drew J. Schwartz

Affiliation Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University in St. Louis, St. Louis, Missouri, United States of America

Matt S. Conover

Affiliation Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University in St. Louis, St. Louis, Missouri, United States of America

Thomas J. Hannan

Affiliation Department of Pathology & Immunology, Washington University in St. Louis, St. Louis, Missouri, United States of America

Scott J. Hultgren

* E-mail: Hultgren@wusm.wustl.edu

Affiliation Department of Molecular Microbiology, Center for Women's Infectious Disease Research, Washington University in St. Louis, St. Louis, Missouri, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DJS TJH SJH. Performed the experiments: DJS MSC TJH. Analyzed the data: DJS MSC TJH SJH. Contributed reagents/materials/analysis tools: MSC TJH. Wrote the paper: DJS SJH. Edited the manuscript: MSC TJH.

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Cystitis
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Bladder
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Mouse models
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Superinfection
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Urinary tract infections
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Cytokines
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Kidneys
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