Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90

Terence N. Bukong; Fatemeh Momen-Heravi; Karen Kodys; Shashi Bala; Gyongyi Szabo

doi:10.1371/journal.ppat.1004424

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Open Access

Peer-reviewed

Research Article

Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90

Terence N. Bukong ,

Contributed equally to this work with: Terence N. Bukong, Fatemeh Momen-Heravi

Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Fatemeh Momen-Heravi ,

Contributed equally to this work with: Terence N. Bukong, Fatemeh Momen-Heravi

Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Karen Kodys,

Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Shashi Bala,

Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯
Gyongyi Szabo

* E-mail: Gyongyi.Szabo@umassmed.edu

Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
⨯

Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90

Terence N. Bukong,
Fatemeh Momen-Heravi,
Karen Kodys,
Shashi Bala,
Gyongyi Szabo

Published: October 2, 2014
https://doi.org/10.1371/journal.ppat.1004424

About the Authors

Terence N. Bukong

Contributed equally to this work with: Terence N. Bukong, Fatemeh Momen-Heravi

Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Fatemeh Momen-Heravi

Contributed equally to this work with: Terence N. Bukong, Fatemeh Momen-Heravi

Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Karen Kodys

Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Shashi Bala

Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Gyongyi Szabo

* E-mail: Gyongyi.Szabo@umassmed.edu

Affiliation Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TNB GS. Performed the experiments: TNB FMH KK SB. Analyzed the data: TNB FMH GS. Contributed reagents/materials/analysis tools: GS. Wrote the paper: TNB FMH GS.

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Exosomes
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Hepatitis C virus
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RNA analysis
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Hepatocytes
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Antibodies
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RNA extraction
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Small interfering RNA
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Antibody therapy
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