cGMP and NHR Signaling Co-regulate Expression of Insulin-Like Peptides and Developmental Activation of Infective Larvae in Strongyloides stercoralis

Jonathan D. Stoltzfus; Stephen M. Bart; James B. Lok

doi:10.1371/journal.ppat.1004235

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Open Access

Peer-reviewed

Research Article

cGMP and NHR Signaling Co-regulate Expression of Insulin-Like Peptides and Developmental Activation of Infective Larvae in Strongyloides stercoralis

Jonathan D. Stoltzfus,

Affiliations Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, Department of Biology, Hollins University, Roanoke, Virginia, United States of America
⨯
Stephen M. Bart,

Affiliation Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
⨯
James B. Lok

* E-mail: jlok@vet.upenn.edu

Affiliation Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
⨯

cGMP and NHR Signaling Co-regulate Expression of Insulin-Like Peptides and Developmental Activation of Infective Larvae in Strongyloides stercoralis

Jonathan D. Stoltzfus,
Stephen M. Bart,
James B. Lok

Published: July 10, 2014
https://doi.org/10.1371/journal.ppat.1004235

About the Authors

Jonathan D. Stoltzfus

Affiliations Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, Department of Biology, Hollins University, Roanoke, Virginia, United States of America

Stephen M. Bart

Affiliation Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America

James B. Lok

* E-mail: jlok@vet.upenn.edu

Affiliation Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JDS JBL. Performed the experiments: JDS SMB. Analyzed the data: JDS JBL. Wrote the paper: JDS SMB JBL.

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Strongyloides stercoralis
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Caenorhabditis elegans
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cGMP signaling
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Larvae
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G protein coupled receptors
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Hormone receptor signaling
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Parasitic diseases
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Nematode infections
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