Mitogen and Stress Activated Kinases Act Co-operatively with CREB during the Induction of Human Cytomegalovirus Immediate-Early Gene Expression from Latency

Verity G. Kew; Jinxiang Yuan; Jeffery Meier; Matthew B. Reeves

doi:10.1371/journal.ppat.1004195

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Open Access

Peer-reviewed

Research Article

Mitogen and Stress Activated Kinases Act Co-operatively with CREB during the Induction of Human Cytomegalovirus Immediate-Early Gene Expression from Latency

Verity G. Kew,

Affiliation Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom
⨯
Jinxiang Yuan,

Affiliation Department of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Jeffery Meier,

Affiliation Department of Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Matthew B. Reeves

* E-mail: matthew.reeves@ucl.ac.uk

Affiliations Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom, Institute of Immunity & Transplantation, Division of Infection & Immunity, Royal Free Hospital, University College London, London, United Kingdom
⨯

Mitogen and Stress Activated Kinases Act Co-operatively with CREB during the Induction of Human Cytomegalovirus Immediate-Early Gene Expression from Latency

Verity G. Kew,
Jinxiang Yuan,
Jeffery Meier,
Matthew B. Reeves

Published: June 12, 2014
https://doi.org/10.1371/journal.ppat.1004195

About the Authors

Verity G. Kew

Affiliation Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom

Jinxiang Yuan

Affiliation Department of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Jeffery Meier

Affiliation Department of Medicine, University of Iowa, Iowa City, Iowa, United States of America

Matthew B. Reeves

* E-mail: matthew.reeves@ucl.ac.uk

Affiliations Department of Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom, Institute of Immunity & Transplantation, Division of Infection & Immunity, Royal Free Hospital, University College London, London, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JM MBR. Performed the experiments: VGK JY MBR. Analyzed the data: JM MBR. Contributed reagents/materials/analysis tools: JY. Wrote the paper: MBR.

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Histones
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Gene expression
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Phosphorylation
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Monocytes
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Cell differentiation
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Signal amplification
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ERK signaling cascade
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CREB signaling
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