About the Authors

Yasushi Itoh

Contributed equally to this work with: Yasushi Itoh, Reiko Yoshida

Affiliation Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan

Reiko Yoshida

Contributed equally to this work with: Yasushi Itoh, Reiko Yoshida

Affiliation Division of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan

Shintaro Shichinohe

Affiliation Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan

Megumi Higuchi

Affiliation Division of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan

Hirohito Ishigaki

Affiliation Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan

Misako Nakayama

Affiliation Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan

Van Loi Pham

Affiliation Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan

Hideaki Ishida

Affiliation Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan

Mitsutaka Kitano

Affiliations Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan, Infectious Diseases, Medicinal Research Laboratories, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan

Masahiko Arikata

Affiliation Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan

Naoko Kitagawa

Affiliation Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan

Yachiyo Mitsuishi

Affiliation Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan

Kazumasa Ogasawara

Affiliation Department of Pathology, Shiga University of Medical Science, Otsu, Shiga, Japan

Hideaki Tsuchiya

Affiliation Research Center for Animal Life Science, Shiga University of Medical Science, Otsu, Shiga, Japan

Takahiro Hiono

Affiliation Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan

Masatoshi Okamatsu

Affiliation Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan

Yoshihiro Sakoda

Affiliation Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan

Hiroshi Kida

Affiliation Laboratory of Microbiology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan

Mutsumi Ito

Affiliation Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Le Quynh Mai

Affiliation National Institute of Hygiene and Epidemiology, Hanoi, Vietnam

Yoshihiro Kawaoka

Affiliations Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, United States of America

Hiroko Miyamoto

Affiliation Division of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan

Mari Ishijima

Affiliation Division of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan

Manabu Igarashi

Affiliation Division of Bioinformatics, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan

Yasuhiko Suzuki

Affiliation Division of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan

Ayato Takada

atakada@czc.hokudai.ac.jp

Affiliation Division of Global Epidemiology, Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan

Competing Interests

MK is employed by Shionogi & Co., Ltd., a company developing the neuraminidase inhibitor used in this study. This does not alter our adherence to all PLOS Pathogens policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: YI RY KO AT. Performed the experiments: YI RY SS MH HIshig MN VLP HIshid MA NK YM TH MO YS HM MIs. Analyzed the data: YI RY MIg AT. Contributed reagents/materials/analysis tools: MK HT HK MIt LQM YK YS. Wrote the paper: YI RY AT.