Activation of Focal Adhesion Kinase by Salmonella Suppresses Autophagy via an Akt/mTOR Signaling Pathway and Promotes Bacterial Survival in Macrophages

Katherine A. Owen; Corey B. Meyer; Amy H. Bouton; James E. Casanova

doi:10.1371/journal.ppat.1004159

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Open Access

Peer-reviewed

Research Article

Activation of Focal Adhesion Kinase by Salmonella Suppresses Autophagy via an Akt/mTOR Signaling Pathway and Promotes Bacterial Survival in Macrophages

Katherine A. Owen,

Affiliation Department of Cell Biology, University of Virginia Health System, Charlottesville, Virginia, United States of America
⨯
Corey B. Meyer,

Affiliation Department of Cell Biology, University of Virginia Health System, Charlottesville, Virginia, United States of America
⨯
Amy H. Bouton,

Affiliation Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia, United States of America
⨯
James E. Casanova

* E-mail: jec9e@virginia.edu

Affiliations Department of Cell Biology, University of Virginia Health System, Charlottesville, Virginia, United States of America, Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia, United States of America
⨯

Activation of Focal Adhesion Kinase by Salmonella Suppresses Autophagy via an Akt/mTOR Signaling Pathway and Promotes Bacterial Survival in Macrophages

Katherine A. Owen,
Corey B. Meyer,
Amy H. Bouton,
James E. Casanova

Published: June 5, 2014
https://doi.org/10.1371/journal.ppat.1004159

About the Authors

Katherine A. Owen

Affiliation Department of Cell Biology, University of Virginia Health System, Charlottesville, Virginia, United States of America

Corey B. Meyer

Affiliation Department of Cell Biology, University of Virginia Health System, Charlottesville, Virginia, United States of America

Amy H. Bouton

Affiliation Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia, United States of America

James E. Casanova

* E-mail: jec9e@virginia.edu

Affiliations Department of Cell Biology, University of Virginia Health System, Charlottesville, Virginia, United States of America, Department of Microbiology, University of Virginia Health System, Charlottesville, Virginia, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KAO JEC CBM. Performed the experiments: KAO CBM. Analyzed the data: KAO JEC. Contributed reagents/materials/analysis tools: KAO JEC CBM AHB. Wrote the paper: KAO JEC.

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Salmonella
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Macrophages
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Salmonella typhimurium
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Autophagic cell death
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Salmonellosis
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Intracellular pathogens
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Immunoblotting
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Signal inhibition
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