Efficient Parvovirus Replication Requires CRL4Cdt2-Targeted Depletion of p21 to Prevent Its Inhibitory Interaction with PCNA

Richard O. Adeyemi; Matthew S. Fuller; David J. Pintel

doi:10.1371/journal.ppat.1004055

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Peer-reviewed

Research Article

Efficient Parvovirus Replication Requires CRL4^Cdt2-Targeted Depletion of p21 to Prevent Its Inhibitory Interaction with PCNA

Richard O. Adeyemi ,

Contributed equally to this work with: Richard O. Adeyemi, Matthew S. Fuller

Affiliation Department of Molecular Microbiology and Immunology, C.S. Bond Life Sciences Center, University of Missouri-Columbia, School of Medicine, Columbia, Missouri, United States of America
⨯
Matthew S. Fuller ,

Contributed equally to this work with: Richard O. Adeyemi, Matthew S. Fuller

Affiliation Department of Molecular Microbiology and Immunology, C.S. Bond Life Sciences Center, University of Missouri-Columbia, School of Medicine, Columbia, Missouri, United States of America
⨯
David J. Pintel

* E-mail: pinteld@missouri.edu

Affiliation Department of Molecular Microbiology and Immunology, C.S. Bond Life Sciences Center, University of Missouri-Columbia, School of Medicine, Columbia, Missouri, United States of America
⨯

Efficient Parvovirus Replication Requires CRL4^Cdt2-Targeted Depletion of p21 to Prevent Its Inhibitory Interaction with PCNA

Richard O. Adeyemi,
Matthew S. Fuller,
David J. Pintel

Published: April 3, 2014
https://doi.org/10.1371/journal.ppat.1004055

About the Authors

Richard O. Adeyemi

Contributed equally to this work with: Richard O. Adeyemi, Matthew S. Fuller

Affiliation Department of Molecular Microbiology and Immunology, C.S. Bond Life Sciences Center, University of Missouri-Columbia, School of Medicine, Columbia, Missouri, United States of America

Matthew S. Fuller

Contributed equally to this work with: Richard O. Adeyemi, Matthew S. Fuller

Affiliation Department of Molecular Microbiology and Immunology, C.S. Bond Life Sciences Center, University of Missouri-Columbia, School of Medicine, Columbia, Missouri, United States of America

David J. Pintel

* E-mail: pinteld@missouri.edu

Affiliation Department of Molecular Microbiology and Immunology, C.S. Bond Life Sciences Center, University of Missouri-Columbia, School of Medicine, Columbia, Missouri, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ROA MSF DJP. Performed the experiments: ROA MSF. Analyzed the data: ROA MSF DJP. Contributed reagents/materials/analysis tools: ROA MSF DJP. Wrote the paper: ROA MSF DJP.

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Viral replication
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Ligases
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DNA replication
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Small interfering RNA
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Synthesis phase
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Ubiquitin ligases
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DNA damage
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DNA polymerase
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