Rotavirus Activates Lymphocytes from Non-Obese Diabetic Mice by Triggering Toll-Like Receptor 7 Signaling and Interferon Production in Plasmacytoid Dendritic Cells

Jessica A. Pane; Nicole L. Webster; Barbara S. Coulson

doi:10.1371/journal.ppat.1003998

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Open Access

Peer-reviewed

Research Article

Rotavirus Activates Lymphocytes from Non-Obese Diabetic Mice by Triggering Toll-Like Receptor 7 Signaling and Interferon Production in Plasmacytoid Dendritic Cells

Jessica A. Pane,

Affiliation Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
⨯
Nicole L. Webster,

Affiliation Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
⨯
Barbara S. Coulson

* E-mail: barbarac@unimelb.edu.au

Affiliation Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia
⨯

Rotavirus Activates Lymphocytes from Non-Obese Diabetic Mice by Triggering Toll-Like Receptor 7 Signaling and Interferon Production in Plasmacytoid Dendritic Cells

Jessica A. Pane,
Nicole L. Webster,
Barbara S. Coulson

Published: March 27, 2014
https://doi.org/10.1371/journal.ppat.1003998

About the Authors

Jessica A. Pane

Affiliation Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia

Nicole L. Webster

Affiliation Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia

Barbara S. Coulson

* E-mail: barbarac@unimelb.edu.au

Affiliation Department of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JAP NLW BSC. Performed the experiments: JAP. Analyzed the data: JAP BSC NLW. Contributed reagents/materials/analysis tools: JAP BSC NLW. Wrote the paper: JAP BSC NLW.

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B cells
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Antigen-presenting cells
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T cells
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Rotavirus
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Rotavirus infection
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Diabetes mellitus
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Mouse models
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Cytotoxic T cells
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