Engagement of NKG2D on Bystander Memory CD8 T Cells Promotes Increased Immunopathology following Leishmania major Infection

Erika J. Crosby; Michael H. Goldschmidt; E. John Wherry; Phillip Scott

doi:10.1371/journal.ppat.1003970

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Peer-reviewed

Research Article

Engagement of NKG2D on Bystander Memory CD8 T Cells Promotes Increased Immunopathology following Leishmania major Infection

Erika J. Crosby,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Michael H. Goldschmidt,

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
E. John Wherry,

Affiliation Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Phillip Scott

* E-mail: pscott@vet.upenn.edu

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Engagement of NKG2D on Bystander Memory CD8 T Cells Promotes Increased Immunopathology following Leishmania major Infection

Erika J. Crosby,
Michael H. Goldschmidt,
E. John Wherry,
Phillip Scott

Published: February 27, 2014
https://doi.org/10.1371/journal.ppat.1003970

About the Authors

Erika J. Crosby

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Michael H. Goldschmidt

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

E. John Wherry

Affiliation Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Phillip Scott

* E-mail: pscott@vet.upenn.edu

Affiliation Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EJC EJW PS. Performed the experiments: EJC. Analyzed the data: EJC MHG. Contributed reagents/materials/analysis tools: EJW PS. Wrote the paper: EJC PS.

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T cells
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Cytotoxic T cells
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Parasitic diseases
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Skin infections
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Ear infections
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Immune response
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Flow cytometry
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Immunopathology
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