Competitive and Cooperative Interactions Mediate RNA Transfer from Herpesvirus Saimiri ORF57 to the Mammalian Export Adaptor ALYREF

Richard B. Tunnicliffe; Guillaume M. Hautbergue; Stuart A. Wilson; Priti Kalra; Alexander P. Golovanov

doi:10.1371/journal.ppat.1003907

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Open Access

Peer-reviewed

Research Article

Competitive and Cooperative Interactions Mediate RNA Transfer from Herpesvirus Saimiri ORF57 to the Mammalian Export Adaptor ALYREF

Richard B. Tunnicliffe,

Affiliation Manchester Institute of Biotechnology and Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Guillaume M. Hautbergue,

Affiliation RNA Biology Laboratory, Sheffield Institute for Translational Neuroscience, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom
⨯
Stuart A. Wilson,

Affiliation Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom
⨯
Priti Kalra,

Affiliation Manchester Institute of Biotechnology and Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯
Alexander P. Golovanov

* E-mail: A.Golovanov@manchester.ac.uk

Affiliation Manchester Institute of Biotechnology and Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
⨯

Competitive and Cooperative Interactions Mediate RNA Transfer from Herpesvirus Saimiri ORF57 to the Mammalian Export Adaptor ALYREF

Richard B. Tunnicliffe,
Guillaume M. Hautbergue,
Stuart A. Wilson,
Priti Kalra,
Alexander P. Golovanov

Published: February 13, 2014
https://doi.org/10.1371/journal.ppat.1003907

About the Authors

Richard B. Tunnicliffe

Affiliation Manchester Institute of Biotechnology and Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

Guillaume M. Hautbergue

Affiliation RNA Biology Laboratory, Sheffield Institute for Translational Neuroscience, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom

Stuart A. Wilson

Affiliation Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom

Priti Kalra

Affiliation Manchester Institute of Biotechnology and Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

Alexander P. Golovanov

* E-mail: A.Golovanov@manchester.ac.uk

Affiliation Manchester Institute of Biotechnology and Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: APG. Performed the experiments: RBT GMH PK APG. Analyzed the data: RBT APG GMH SAW. Contributed reagents/materials/analysis tools: PK. Wrote the paper: APG RBT.

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Transfer RNA
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RNA-binding proteins
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RNA structure
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Amides
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Messenger RNA
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Viral structure
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Cell binding
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Sequence motif analysis
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