Toxoplasma gondii Relies on Both Host and Parasite Isoprenoids and Can Be Rendered Sensitive to Atorvastatin

Zhu-Hong Li; Srinivasan Ramakrishnan; Boris Striepen; Silvia N. J. Moreno

doi:10.1371/journal.ppat.1003665

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Peer-reviewed

Research Article

Toxoplasma gondii Relies on Both Host and Parasite Isoprenoids and Can Be Rendered Sensitive to Atorvastatin

Zhu-Hong Li,

Affiliation Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America
⨯
Srinivasan Ramakrishnan,

Affiliation Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America
⨯
Boris Striepen,

Affiliation Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America
⨯
Silvia N. J. Moreno

* E-mail: smoreno@uga.edu

Affiliation Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America
⨯

Toxoplasma gondii Relies on Both Host and Parasite Isoprenoids and Can Be Rendered Sensitive to Atorvastatin

Zhu-Hong Li,
Srinivasan Ramakrishnan,
Boris Striepen,
Silvia N. J. Moreno

Published: October 17, 2013
https://doi.org/10.1371/journal.ppat.1003665

About the Authors

Zhu-Hong Li

Affiliation Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

Srinivasan Ramakrishnan

Affiliation Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

Boris Striepen

Affiliation Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

Silvia N. J. Moreno

* E-mail: smoreno@uga.edu

Affiliation Center for Tropical and Emerging Global Diseases and Department of Cellular Biology, University of Georgia, Athens, Georgia, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZHL SR BS SNJM. Performed the experiments: ZHL SR. Analyzed the data: ZHL SR BS SNJM. Contributed reagents/materials/analysis tools: ZHL SR BS SNJM. Wrote the paper: ZHL BS SNJM.

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Parasitic diseases
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Isoprenoids
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Toxoplasma gondii
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Tachyzoites
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Host cells
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Fibroblasts
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Macrophages
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Statins
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