Calcineurin Plays Key Roles in the Dimorphic Transition and Virulence of the Human Pathogenic Zygomycete Mucor circinelloides

Soo Chan Lee; Alicia Li; Silvia Calo; Joseph Heitman

doi:10.1371/journal.ppat.1003625

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Peer-reviewed

Research Article

Calcineurin Plays Key Roles in the Dimorphic Transition and Virulence of the Human Pathogenic Zygomycete Mucor circinelloides

Soo Chan Lee,

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Alicia Li,

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Silvia Calo,

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯
Joseph Heitman

* E-mail: heitm001@duke.edu

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America
⨯

Calcineurin Plays Key Roles in the Dimorphic Transition and Virulence of the Human Pathogenic Zygomycete Mucor circinelloides

Soo Chan Lee,
Alicia Li,
Silvia Calo,
Joseph Heitman

Published: September 5, 2013
https://doi.org/10.1371/journal.ppat.1003625

About the Authors

Soo Chan Lee

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

Alicia Li

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

Silvia Calo

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

Joseph Heitman

* E-mail: heitm001@duke.edu

Affiliation Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SCL JH. Performed the experiments: SCL AL SC. Analyzed the data: SCL JH SC. Contributed reagents/materials/analysis tools: JH. Wrote the paper: SCL AL SC JH.

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Yeast infections
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Candida albicans
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Zygomycetes
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Gene disruption
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