About the Authors

Marco Binder

Contributed equally to this work with: Marco Binder, Nurgazy Sulaimanov

Affiliation Heidelberg University, Medical Faculty, Department of Infectious Diseases, Molecular Virology, Heidelberg, Germany

Nurgazy Sulaimanov

Contributed equally to this work with: Marco Binder, Nurgazy Sulaimanov

Affiliations Technische Universität Dresden, Institute for Medical Informatics and Biometry, Dresden, Germany, Heidelberg University, ViroQuant Research Group Modeling, BioQuant BQ26, Heidelberg, Germany

Diana Clausznitzer

Affiliation Technische Universität Dresden, Institute for Medical Informatics and Biometry, Dresden, Germany

Manuel Schulze

Affiliation Technische Universität Dresden, Institute for Medical Informatics and Biometry, Dresden, Germany

Christian M. Hüber

Current address: Department of Obstetrics and Gynaecology, University of Cambridge Clinical School, The Rosie Hospital, Cambridge, United Kingdom.

Affiliation Heidelberg University, Medical Faculty, Department of Infectious Diseases, Molecular Virology, Heidelberg, Germany

Simon M. Lenz

Affiliation Heidelberg University, Interdisciplinary Center for Scientific Computing (IWR), Simulation and Optimization Group, Heidelberg, Germany

Johannes P. Schlöder

Affiliation Heidelberg University, Interdisciplinary Center for Scientific Computing (IWR), Simulation and Optimization Group, Heidelberg, Germany

Martin Trippler

Affiliation University Hospital of Essen, Department of Gastroenterology and Hepatology, Essen, Germany

Ralf Bartenschlager

Affiliation Heidelberg University, Medical Faculty, Department of Infectious Diseases, Molecular Virology, Heidelberg, Germany

Volker Lohmann

Affiliation Heidelberg University, Medical Faculty, Department of Infectious Diseases, Molecular Virology, Heidelberg, Germany

Lars Kaderali

lars.kaderali@tu-dresden.de

Affiliations Technische Universität Dresden, Institute for Medical Informatics and Biometry, Dresden, Germany, Heidelberg University, ViroQuant Research Group Modeling, BioQuant BQ26, Heidelberg, Germany

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MB LK. Performed the experiments: MB CMH MT VL RB. Analyzed the data: NS DC MS SML JPS MB LK. Wrote the paper: NS MB VL LK. Developed the models: NS MB LK. Performed multiple shooting optimization and analysis: SML JPS.