About the Authors
- Stephanie Traub
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Affiliation National Heart and Lung Institute, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom
- Alexandra Nikonova
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Affiliation National Heart and Lung Institute, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom
- Alan Carruthers
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Affiliation MedImmune Ltd, Cambridge, United Kingdom
- Rebecca Dunmore
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Affiliation MedImmune Ltd, Cambridge, United Kingdom
- Katherine A. Vousden
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Affiliation MedImmune Ltd, Cambridge, United Kingdom
- Leila Gogsadze
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Affiliation National Heart and Lung Institute, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom
- Weidong Hao
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Affiliation MedImmune LLC, Gaithersburg, Maryland, United States of America
- Qing Zhu
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Affiliation MedImmune LLC, Gaithersburg, Maryland, United States of America
- Katie Bernard
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Affiliation MedImmune LLC, Gaithersburg, Maryland, United States of America
- Jie Zhu
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Affiliation National Heart and Lung Institute, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom
- Michael Dymond
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Affiliation AstraZeneca, Charnwood, United Kingdom
- Gary R. McLean
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Affiliation National Heart and Lung Institute, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom
- Ross P. Walton
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Affiliation National Heart and Lung Institute, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom
- Nicholas Glanville
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Affiliation National Heart and Lung Institute, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom
- Alison Humbles
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Affiliation MedImmune LLC, Gaithersburg, Maryland, United States of America
- Musa Khaitov
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Affiliation NRC Institute of Immunology FMBA, Moscow, Russia
- Ted Wells
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Affiliation AstraZeneca, Charnwood, United Kingdom
- Roland Kolbeck
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Affiliation MedImmune LLC, Gaithersburg, Maryland, United States of America
- Andrew J. Leishman
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Affiliation AstraZeneca, Charnwood, United Kingdom
- Matthew A. Sleeman
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Affiliation MedImmune Ltd, Cambridge, United Kingdom
- Nathan W. Bartlett
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Contributed equally to this work with: Nathan W. Bartlett, Sebastian L. Johnston
Affiliation National Heart and Lung Institute, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom
- Sebastian L. Johnston
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Contributed equally to this work with: Nathan W. Bartlett, Sebastian L. Johnston
* E-mail: s.johnston@imperial.ac.uk
Affiliation National Heart and Lung Institute, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Centre for Respiratory Infection, Imperial College London, London, United Kingdom
Competing Interests
The following authors (AC, RD, KAV, WH, QZ, AH, RK, MAS, KB, MD, TW, AJL) are full time employees of MedImmune Ltd. or MedImmune LLC, wholly owned subsidiaries of Astrazeneca PLC. As employees they also receive shares and share options in the Astrazeneca Group. During the course of the study the following authors (AJL, TW) were employees of Astrazeneca PLC and received shares and share options. Astrazeneca is a global pharmaceutical company that conducts basic research and clinical trials in respiratory diseases such as severe asthma and chronic obstructive pulmonary disease. This work was in part funded by MedImmune and Astrazeneca PLC. This does not alter our adherence to all PLoS Pathogens policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: SLJ NWB ST MAS AC RK AJL AH TW. Performed the experiments: ST NWB RPW NG AN LG JZ GRM AC RK AH RD QZ WH KB MD. Analyzed the data: ST NWB SLJ AC RD RK MAS AJL AH. Contributed reagents/materials/analysis tools: MAS KAV MK. Wrote the paper: ST NWB SLJ MAS KAV.