HIF-1α Is Essential for Effective PMN Bacterial Killing, Antimicrobial Peptide Production and Apoptosis in Pseudomonas aeruginosa Keratitis

Elizabeth A. Berger; Sharon A. McClellan; Kerry S. Vistisen; Linda D. Hazlett

doi:10.1371/journal.ppat.1003457

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Open Access

Peer-reviewed

Research Article

HIF-1α Is Essential for Effective PMN Bacterial Killing, Antimicrobial Peptide Production and Apoptosis in Pseudomonas aeruginosa Keratitis

Elizabeth A. Berger,

Affiliation Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Sharon A. McClellan,

Affiliation Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Kerry S. Vistisen,

Affiliation Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯
Linda D. Hazlett

* E-mail: lhazlett@med.wayne.edu

Affiliation Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America
⨯

HIF-1α Is Essential for Effective PMN Bacterial Killing, Antimicrobial Peptide Production and Apoptosis in Pseudomonas aeruginosa Keratitis

Elizabeth A. Berger,
Sharon A. McClellan,
Kerry S. Vistisen,
Linda D. Hazlett

Published: July 18, 2013
https://doi.org/10.1371/journal.ppat.1003457

About the Authors

Elizabeth A. Berger

Affiliation Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America

Sharon A. McClellan

Affiliation Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America

Kerry S. Vistisen

Affiliation Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America

Linda D. Hazlett

* E-mail: lhazlett@med.wayne.edu

Affiliation Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LDH EAB. Performed the experiments: LDH EAB SAM KSV. Analyzed the data: LDH EAB. Contributed reagents/materials/analysis tools: SAM. Wrote the paper: EAB LDH.

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Cornea
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Pseudomonas aeruginosa
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