Host Defense and Recruitment of Foxp3+ T Regulatory Cells to the Lungs in Chronic Mycobacterium tuberculosis Infection Requires Toll-like Receptor 2

Amanda McBride; Jill Konowich; Padmini Salgame

doi:10.1371/journal.ppat.1003397

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Open Access

Peer-reviewed

Research Article

Host Defense and Recruitment of Foxp3⁺ T Regulatory Cells to the Lungs in Chronic Mycobacterium tuberculosis Infection Requires Toll-like Receptor 2

Amanda McBride,

Affiliation UMDNJ-New Jersey Medical School, Department of Medicine, Centre for Emerging Pathogens Newark, Newark, New Jersey, United States of America
⨯
Jill Konowich,

Affiliation UMDNJ-New Jersey Medical School, Department of Medicine, Centre for Emerging Pathogens Newark, Newark, New Jersey, United States of America
⨯
Padmini Salgame

* E-mail: salgampa@umdnj.edu

Affiliation UMDNJ-New Jersey Medical School, Department of Medicine, Centre for Emerging Pathogens Newark, Newark, New Jersey, United States of America
⨯

Host Defense and Recruitment of Foxp3⁺ T Regulatory Cells to the Lungs in Chronic Mycobacterium tuberculosis Infection Requires Toll-like Receptor 2

Amanda McBride,
Jill Konowich,
Padmini Salgame

Published: June 13, 2013
https://doi.org/10.1371/journal.ppat.1003397

About the Authors

Amanda McBride

Affiliation UMDNJ-New Jersey Medical School, Department of Medicine, Centre for Emerging Pathogens Newark, Newark, New Jersey, United States of America

Jill Konowich

Affiliation UMDNJ-New Jersey Medical School, Department of Medicine, Centre for Emerging Pathogens Newark, Newark, New Jersey, United States of America

Padmini Salgame

* E-mail: salgampa@umdnj.edu

Affiliation UMDNJ-New Jersey Medical School, Department of Medicine, Centre for Emerging Pathogens Newark, Newark, New Jersey, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AM JK PS. Performed the experiments: AM JK. Analyzed the data: AM JK PS. Contributed reagents/materials/analysis tools: PS. Wrote the paper: AM JK PS.

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Mycobacterium tuberculosis
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Regulatory T cells
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Inflammation
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Macrophages
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Toll-like receptors
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Spleen
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T cells
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Immune receptor signaling
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