The HPV16 E6 Oncoprotein Causes Prolonged Receptor Protein Tyrosine Kinase Signaling and Enhances Internalization of Phosphorylated Receptor Species

Jennifer M. Spangle; Karl Munger

doi:10.1371/journal.ppat.1003237

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Open Access

Peer-reviewed

Research Article

The HPV16 E6 Oncoprotein Causes Prolonged Receptor Protein Tyrosine Kinase Signaling and Enhances Internalization of Phosphorylated Receptor Species

Jennifer M. Spangle,

Affiliation Division of Infectious Diseases, Brigham and Women's Hospital, Department of Medicine and Committee on Virology, Harvard Medical School, Boston, Massachusetts, United States of America
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Karl Munger

* E-mail: Kmunger@rics.bwh.harvard.edu

Affiliation Division of Infectious Diseases, Brigham and Women's Hospital, Department of Medicine and Committee on Virology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

The HPV16 E6 Oncoprotein Causes Prolonged Receptor Protein Tyrosine Kinase Signaling and Enhances Internalization of Phosphorylated Receptor Species

Jennifer M. Spangle,
Karl Munger

Published: March 14, 2013
https://doi.org/10.1371/journal.ppat.1003237

About the Authors

Jennifer M. Spangle

Affiliation Division of Infectious Diseases, Brigham and Women's Hospital, Department of Medicine and Committee on Virology, Harvard Medical School, Boston, Massachusetts, United States of America

Karl Munger

* E-mail: Kmunger@rics.bwh.harvard.edu

Affiliation Division of Infectious Diseases, Brigham and Women's Hospital, Department of Medicine and Committee on Virology, Harvard Medical School, Boston, Massachusetts, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JMS KM. Performed the experiments: JMS. Analyzed the data: JMS KM. Contributed reagents/materials/analysis tools: JMS. Wrote the paper: JMS KM.

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HPV-16
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MAPK signaling cascades
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Growth factors
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Phosphorylation
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EGFR signaling
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Human papillomavirus infection
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Protein kinase signaling cascade
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Cell migration
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